Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 10/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28797862 | 0.77 | KDM4E (0.38) | SIRT2METAP2PARP1ADRA1ATSHR | |
| SCHEMBL27871688 | 0.77 | KCNH2 (0.46) | ADRA1ATSHRKDM4EALDH1A1MAPT | |
| SCHEMBL27814421 | 0.74 | PARP1 (0.55) | SIRT2TP53PARP1 | |
| Hydrochloric Acid SCHEMBL27637867 | 0.72 | PARP1 (0.54) | SIRT2TP53PARP1 | |
| SCHEMBL27802575 | 0.72 | PARP1 (0.51) | SIRT2TP53METAP2PARP1ADRA1A | |
| SCHEMBL27806404 | 0.72 | PARP1 (0.51) | SIRT2TP53METAP2PARP1ADRA1A | |
| SCHEMBL161226 | 0.72 | KDM4E (0.50) | SIRT2TP53METAP2PARP1ADRA1A | |
| SCHEMBL28944768 | 0.72 | PARP1 (0.54) | PARP1 | |
| SCHEMBL27823213 | 0.72 | PARP1 (0.54) | PARP1 | |
| SCHEMBL307050 | 0.71 | KDM4E (0.53) | SIRT2TP53METAP2PARP1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3373920-A1 | METHODS AND COMPOSITIONS FOR TREATING ALCOHOL USE DISORDERS | Sanna, Pietro Paolo (US) | 2018-09-19 | — | — | EP | disclosed |
| US-10039772-B2 | Methods and compositions for treating alcohol use disorders | SANNA PIETRO PAOLO (US) | 2018-08-07 | — | — | US | disclosed |
| US-20170232007-A1 | METHODS AND COMPOSITIONS FOR TREATING ALCOHOL USE DISORDERS | SANNA PIETRO PAOLO (US) | 2017-08-17 | — | — | US | disclosed |
| WO-2017083795-A1 | METHODS AND COMPOSITIONS FOR TREATING ALCOHOL USE DISORDERS | SANNA PIETRO PAOLO (US) | 2017-05-18 | — | — | WO | disclosed |
| WO-2008071169-A2 | METHOD FOR THE PRODUCTION OF SPECIFIC INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE, IN PARTICULAR TYPE 1 WITH BASIC NOR-OLEANAN OR NOR-URSAN FRAMEWORKS | UNIVERSITÄTSKLINIKUM SCHLESWIG-HOLSTEIN (DE) | 2008-06-19 | — | — | WO | disclosed |
| US-4480099-A | Decahydroquinolyl benzamides | BEECHAM GROUP P.L.C. (GB) | 1984-10-30 | — | — | US | disclosed |
| EP-0068699-A1 | Decahydroquinolyl benzamides, process for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1983-01-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10039772-B2 | Methods and compositions for treating alcohol use disorders | HSD3B1, HSD11B1, HSD3B2 | SIRT2 4119/4885TP53 4756/4885METAP2 3779/4885 |
| US-20170232007-A1 | METHODS AND COMPOSITIONS FOR TREATING ALCOHOL USE DISORDERS | HSD3B1, HSD11B1, HSD3B2 | SIRT2 4119/4885TP53 4756/4885METAP2 3779/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.