Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SFRP1 | Q8N474 | 17/20 | 0.53 |
| ▸ | WNT3 | P56703 | 4/20 | 0.48 |
| ▸ | CCR8 | P51685 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4784964 | 0.94 | SFRP1 (0.58) | SFRP1WNT3CCR8BRD4TGFBR1 | |
| SCHEMBL4783585 | 0.89 | SFRP1 (0.55) | SFRP1WNT3CCR8BRD4TGFBR1 | |
| SCHEMBL4781750 | 0.87 | SFRP1 (0.57) | SFRP1WNT3 | |
| SCHEMBL4783893 | 0.84 | SFRP1 (0.50) | SFRP1WNT3 | |
| SCHEMBL4783460 | 0.83 | SFRP1 (0.50) | SFRP1WNT3 | |
| SCHEMBL4784924 | 0.83 | SFRP1 (0.55) | SFRP1WNT3 | |
| SCHEMBL4781883 | 0.83 | SFRP1 (0.52) | SFRP1WNT3 | |
| SCHEMBL4783752 | 0.82 | SFRP1 (0.47) | SFRP1WNT3 | |
| SCHEMBL4783125 | 0.82 | CCR8 (0.52) | SFRP1WNT3CCR8BRD4TGFBR1 | |
| SCHEMBL14207869 | 0.82 | CCR8 (0.50) | SFRP1WNT3CCR8BRD4TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |