Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 13/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4781668 | 0.82 | MIF (0.39) | MAPK14MAPK11 | |
| SCHEMBL2363210 | 0.80 | BRAF (0.58) | BRAF | |
| SCHEMBL13436159 | 0.79 | BRAF (0.50) | BRAFMAPK14MAPTLMNA | |
| SCHEMBL4907955 | 0.79 | ESRRA (0.38) | MAPTLMNA | |
| SCHEMBL4782660 | 0.78 | NR1I2 (0.42) | BRAFMAPK14 | |
| SCHEMBL4784135 | 0.77 | CYP1A2 (0.48) | — | |
| SCHEMBL14292741 | 0.77 | MIF (0.38) | — | |
| SCHEMBL15869739 | 0.76 | BRAF (0.47) | BRAFMAPK14LMNA | |
| SCHEMBL15869726 | 0.76 | BRAF (0.58) | BRAF | |
| SCHEMBL4781910 | 0.75 | GSK3A (0.33) | BRAFMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |