Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMYD2 | Q9NRG4 | 3/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | PIP5K1A | Q99755 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | TEK | Q02763 | 2/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4782188 | 0.90 | MEN1 (0.42) | MEN1KMT2ASMYD2ABL1PIP5K1A | |
| SCHEMBL4880891 | 0.88 | TEK (0.38) | MEN1KMT2ATEKNR1I2RAF1 | |
| SCHEMBL4779210 | 0.87 | TEK (0.41) | TEKNR1I2RAF1BRAF | |
| SCHEMBL4783784 | 0.85 | TEK (0.40) | TEKNR1I2RAF1BRAF | |
| SCHEMBL4780039 | 0.85 | TEK (0.40) | TEKSCN9ANR1I2RAF1BRAF | |
| SCHEMBL14293386 | 0.84 | TEK (0.43) | TEKNR1I2RAF1BRAF | |
| SCHEMBL4781611 | 0.84 | TEK (0.39) | TEKKITNR1I2BRAF | |
| SCHEMBL4782195 | 0.84 | GPR119 (0.42) | JAK2TEKNR1I2RAF1BRAF | |
| SCHEMBL4780202 | 0.83 | TEK (0.42) | TEKNR1I2RAF1BRAF | |
| SCHEMBL4782957 | 0.83 | BRAF (0.42) | KMT2ATEKBRAFALDH1A1EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |