Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 13/20 | 0.45 |
| ▸ | RAF1 | P04049 | 10/20 | 0.45 |
| ▸ | DDT | P30046 | 3/20 | 0.41 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.39 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.39 |
| ▸ | CSF1R | P07333 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4781343 | 0.93 | BRAF (0.53) | BRAFRAF1TNK2MAP4K2CSF1R | |
| SCHEMBL4779581 | 0.91 | MAPK14 (0.39) | BRAFRAF1DDT | |
| SCHEMBL4782897 | 0.90 | DDT (0.40) | BRAFRAF1DDT | |
| SCHEMBL4730805 | 0.87 | DDT (0.42) | BRAFRAF1DDTCSF1R | |
| SCHEMBL4726565 | 0.87 | NR2E1 (0.49) | BRAFRAF1TNK2MAP4K2CSF1R | |
| SCHEMBL4728307 | 0.84 | RAF1 (0.45) | BRAFRAF1 | |
| SCHEMBL4727546 | 0.84 | RAF1 (0.36) | BRAFRAF1DDT | |
| SCHEMBL4781339 | 0.83 | BRAF (0.43) | BRAFRAF1DDTTNK2MAP4K2 | |
| SCHEMBL4779575 | 0.82 | ACKR3 (0.34) | BRAFDDT | |
| SCHEMBL4782241 | 0.81 | RAF1 (0.44) | BRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |