Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | AHR | P35869 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4783105 | 1.00 | NOX1 (0.34) | NOX1ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL4897708 | 0.88 | ALDH1A1 (0.34) | NOX1ALDH1A1HSD17B10TSHRMEN1 | |
| SCHEMBL4899050 | 0.87 | ALDH1A1 (0.32) | ALDH1A1HSD17B10TSHRMEN1KMT2A | |
| SCHEMBL4895994 | 0.87 | ALDH1A1 (0.32) | ALDH1A1HSD17B10TSHRMEN1KMT2A | |
| SCHEMBL4899046 | 0.87 | ALDH1A1 (0.32) | ALDH1A1HSD17B10TSHRMEN1KMT2A | |
| SCHEMBL4897704 | 0.86 | MAPT (0.35) | ALDH1A1HSD17B10TSHRMEN1KMT2A | |
| SCHEMBL4899245 | 0.85 | ALDH1A1 (0.30) | ALDH1A1MEN1KMT2AHTTRAB9A | |
| SCHEMBL4891154 | 0.85 | ALDH1A1 (0.30) | ALDH1A1MEN1KMT2AHTTRAB9A | |
| SCHEMBL4899239 | 0.85 | ALDH1A1 (0.30) | ALDH1A1MEN1KMT2AHTTRAB9A | |
| SCHEMBL4896070 | 0.84 | ROCK2 (0.36) | NOX1ALDH1A1KDM4EHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080242694-A1 | Amino-substituted heterocycles, compositions thereof, and methods of treatment therewith | D SIDOCKY NEIL R | 2008-10-02 | — | — | US | disclosed |
| WO-2008036308-A2 | AMINO-SUBSTITUTED HETEROCYCLES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-03-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242694-A1 | Amino-substituted heterocycles, compositions thereof, and methods of treatment therewith | JAK2, CHEK2, MTOR | NOX1 276/4885ALDH1A1 1752/4885KDM4E 1212/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.