Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.39 |
| ▸ | GSK3A | P49840 | 11/20 | 0.36 |
| ▸ | LYN | P07948 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | BUB1 | O43683 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | PRKACG | P22612 | 1/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | ACSL5 | Q9ULC5 | 1/20 | 0.35 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 5/20 | 0.34 |
| ▸ | SYK | P43405 | 5/20 | 0.34 |
| ▸ | HPGDS | O60760 | 3/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4781910 | 0.89 | GSK3A (0.33) | MAPK14GSK3ACYP2C9SRCSYK | |
| SCHEMBL4955400 | 0.85 | BRAF (0.42) | MAPK14LYNMAPK9BRAF | |
| SCHEMBL4782271 | 0.84 | MAPK14 (0.39) | MAPK14GSK3ACYP2C9BRAF | |
| SCHEMBL4784135 | 0.81 | CYP1A2 (0.48) | CYP2C9 | |
| SCHEMBL1384412 | 0.78 | BRAF (0.37) | MAPK14BRAF | |
| SCHEMBL1379672 | 0.78 | BRAF (0.41) | MAPK14GSK3ASRCSYKBRAF | |
| SCHEMBL1378181 | 0.77 | BRAF (0.40) | BRAF | |
| SCHEMBL1380031 | 0.77 | TUBB4A (0.41) | BRAF | |
| SCHEMBL4780945 | 0.75 | DDT (0.33) | — | |
| SCHEMBL6807093 | 0.74 | BRAF (0.49) | MAPK14BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |