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SCHEMBL4783344

SCHEMBL4783344

NC(=O)c1ccccc1-c1ccc(S(=O)(=O)NC2Cc3ccc(C=CC(=O)O)cc3C2)c(C(F)(F)F)c1

nearest known ligand 0.46

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ APOB P04114 13/20 0.46
▸ MTTP P55157 12/20 0.46
▸ NR1H2 P55055 3/20 0.42
▸ SFRP1 Q8N474 3/20 0.39
▸ ALOX5AP P20292 1/20 0.37
▸ FEN1 P39748 1/20 0.37
▸ WNT3 P56703 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4783336 1.00 APOB (0.46) APOBMTTPNR1H2SFRP1ALOX5AP
SCHEMBL4784710 0.94 APOB (0.47) APOBMTTPNR1H2SFRP1ALOX5AP
SCHEMBL4784701 0.94 APOB (0.47) APOBMTTPNR1H2SFRP1ALOX5AP
SCHEMBL4783976 0.92 APOB (0.48) APOBMTTPNR1H2
SCHEMBL4783986 0.92 APOB (0.48) APOBMTTPNR1H2
SCHEMBL4782252 0.91 NR1H2 (0.46) APOBMTTPNR1H2SFRP1ALOX5AP
SCHEMBL4782255 0.91 NR1H2 (0.46) APOBMTTPNR1H2SFRP1ALOX5AP
SCHEMBL4780660 0.89 NR1H2 (0.43) APOBMTTPNR1H2SFRP1ALOX5AP
SCHEMBL4780662 0.89 NR1H2 (0.43) APOBMTTPNR1H2SFRP1ALOX5AP
SCHEMBL4782116 0.89 NR1H2 (0.43) APOBMTTPNR1H2SFRP1WNT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008061006-A1 SUBSTITUTED INDAN-2-YL, TETRAHYDRONAPHTHALEN-2-YL, OR DIHYDR0-2H-CHR0MEN-3-YL ARYLSULFONAMIDES AND METHODS OF THEIR USE WYETH (US) 2008-05-22 — — WO disclosed