Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 4/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 2/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1684112 | 0.78 | MAOB (0.44) | TRPM8MAOBHDAC6 | |
| Hydrochloric Acid SCHEMBL3845059 | 0.72 | TRPM8 (0.45) | TRPM8MAOBNPC1RAB9AHDAC6 | |
| SCHEMBL2948359 | 0.70 | MAOB (0.46) | TRPM8MAOBRAB9AHDAC6HDAC3 | |
| SCHEMBL842840 | 0.70 | HDAC6 (0.52) | TRPM8MAOBHDAC6P4HTM | |
| SCHEMBL30354466 | 0.70 | HDAC6 (0.52) | TRPM8MAOBHDAC6P4HTM | |
| SCHEMBL14875835 | 0.69 | MMP1 (0.47) | TRPM8RIPK1ALOX5CYP19A1HDAC3 | |
| SCHEMBL14876434 | 0.69 | CFTR (0.50) | TRPM8RIPK1ALOX5P4HTM | |
| SCHEMBL13778764 | 0.69 | HDAC6 (0.48) | TRPM8MAOBNPC1RAB9AHDAC6 | |
| SCHEMBL1207795 | 0.69 | HDAC6 (0.48) | TRPM8MAOBRIPK1HDAC6 | |
| SCHEMBL3830566 | 0.68 | HDAC6 (0.47) | TRPM8MAOBNPC1RAB9AHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943249-A1 | INHIBITORS OF THE HIV INTEGRASE ENZYME | Pfizer Products Incorporated (US) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007039802-A1 | INHIBITORS OF THE HIV INTEGRASE ENZYME | PFIZER PRODUCTS INC. (US) | 2007-04-12 | — | — | WO | disclosed |