Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 4/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | RAMP1 | O60894 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1813441 | 0.89 | CALCRL (0.48) | CALCRLRAMP1L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL14161325 | 0.78 | L3MBTL1 (0.38) | CALCRLRAMP1L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL4785266 | 0.75 | PLAT (0.48) | ALDH1A1HSD17B10MAPK1TSHR | |
| SCHEMBL3278017 | 0.69 | CALCRL (0.55) | CALCRLRAMP1L3MBTL1 | |
| SCHEMBL15353780 | 0.69 | GAA (0.54) | L3MBTL1ALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL22397770 | 0.68 | POLB (0.52) | L3MBTL1ALDH1A1SMN1; SMN2NPSR1MEN1 | |
| SCHEMBL13327274 | 0.68 | POLB (0.52) | L3MBTL1ALDH1A1SMN1; SMN2NPSR1MEN1 | |
| SCHEMBL10073695 | 0.68 | MAPT (0.47) | L3MBTL1ALDH1A1KDM4EGAAMAPT | |
| SCHEMBL693889 | 0.68 | L3MBTL1 (0.48) | L3MBTL1ALDH1A1SMN1; SMN2NPSR1MEN1 | |
| SCHEMBL8361479 | 0.67 | L3MBTL1 (0.48) | L3MBTL1ALDH1A1KDM4ESMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008070014-A2 | BIARYL KETONE-SUBSTITUTED PIPERIDINES | NEUROGEN CORPORATION (US) | 2008-06-12 | — | — | WO | disclosed |
| WO-2008060568-A2 | AMIDE-SUBSTITUTED ARYL PIPERIDINES | NEUROGEN CORPORATION (US) | 2008-05-22 | — | — | WO | disclosed |
| WO-2008060568-A2 | AMIDE-SUBSTITUTED ARYL PIPERIDINES | NEUROGEN CORPORATION (US) | 2008-05-22 | — | — | WO | disclosed |