Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 3/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | TSPO | P30536 | 2/20 | 0.57 |
| ▸ | TNF | P01375 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 6/20 | 0.56 |
| ▸ | TBXA2R | P21731 | 6/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | CFTR | P13569 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7085422 | 0.86 | PLA2G2A (0.53) | SMN1; SMN2TSPODRD2TBXA2RKDM4E | |
| SCHEMBL4780057 | 0.84 | CYP2C19 (0.60) | CYP2C19CYP1A2CYP2C9LMNASMN1; SMN2 | |
| SCHEMBL28410934 | 0.83 | CFTR (0.61) | CYP2C19CYP1A2CYP2C9LMNASMN1; SMN2 | |
| SCHEMBL4728304 | 0.82 | CYP1A2 (0.53) | CYP2C19CYP1A2CYP2C9LMNASMN1; SMN2 | |
| SCHEMBL4784820 | 0.81 | CYP2C19 (0.57) | CYP2C19CYP1A2CYP2C9LMNASMN1; SMN2 | |
| SCHEMBL4784826 | 0.81 | CYP2C19 (0.57) | CYP2C19CYP1A2CYP2C9LMNASMN1; SMN2 | |
| SCHEMBL6553446 | 0.78 | AR (0.51) | CYP2C19CYP1A2CYP2C9SMN1; SMN2DRD2 | |
| SCHEMBL19156191 | 0.78 | POLB (0.60) | CYP2C19CYP1A2CYP2C9LMNASMN1; SMN2 | |
| SCHEMBL23997462 | 0.77 | DRD2 (0.75) | LMNADRD2TBXA2RCFTRMAPT | |
| SCHEMBL30336823 | 0.77 | DRD2 (0.75) | LMNADRD2TBXA2RCFTRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033739-A2 | BENZIMIDAZOLE CARBOXAMIDE DERIVATIVES | NEUROGEN CORPORATION (US) | 2008-03-20 | — | — | WO | disclosed |
| WO-2008033739-A2 | BENZIMIDAZOLE CARBOXAMIDE DERIVATIVES | NEUROGEN CORPORATION (US) | 2008-03-20 | — | — | WO | disclosed |