Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.48 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.47 |
| ▸ | ACP3 | P15309 | 2/20 | 0.46 |
| ▸ | CES2 | O00748 | 2/20 | 0.46 |
| ▸ | PNMT | P11086 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | TDO2 | P48775 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL255035 | 0.89 | PNMT (0.55) | DAOPTPN5ACP3CES2PNMT | |
| Ammonia Solution, Strong SCHEMBL27629775 | 0.87 | PNMT (0.53) | DAOPTPN5ACP3CES2PNMT | |
| SCHEMBL28217372 | 0.81 | HDAC4 (0.50) | PTPN5CA1CA2 | |
| SCHEMBL1907531 | 0.81 | CA1 (0.53) | ACP3CES2CA1CA2MMP1 | |
| SCHEMBL2662570 | 0.79 | PTPN5 (0.65) | DAOPTPN5PNMTHTR2AHTR2C | |
| SCHEMBL6705910 | 0.78 | PNMT (0.51) | DAOACP3CES2PNMTHSD11B1 | |
| SCHEMBL8463699 | 0.78 | PNMT (0.51) | DAOACP3CES2PNMTHSD11B1 | |
| SCHEMBL156737 | 0.78 | DAO (0.53) | DAOACP3CES2PNMTHSD11B1 | |
| SCHEMBL8460577 | 0.78 | PNMT (0.51) | DAOACP3CES2PNMTHSD11B1 | |
| SCHEMBL2601113 | 0.77 | DAO (0.59) | DAOACP3CES2PNMTHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061006-A1 | SUBSTITUTED INDAN-2-YL, TETRAHYDRONAPHTHALEN-2-YL, OR DIHYDR0-2H-CHR0MEN-3-YL ARYLSULFONAMIDES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |