Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 15/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4782791 | 0.89 | MEN1 (0.41) | NR1H2MEN1KMT2AGRIA2DRD2 | |
| SCHEMBL4782323 | 0.84 | NR1H2 (0.47) | NR1H2MEN1KMT2ANR1H3 | |
| SCHEMBL4783093 | 0.82 | PSEN1 (0.43) | NR1H2DRD2HTR6HTR1AHTR7 | |
| SCHEMBL4784495 | 0.81 | CA1 (0.44) | NR1H2MEN1KMT2AGRIA2DRD2 | |
| SCHEMBL4782205 | 0.80 | CA1 (0.50) | MEN1KMT2ADRD2HTR6HTR1A | |
| SCHEMBL4797405 | 0.79 | MAPT (0.43) | NR1H2MEN1KMT2AGRIA2DRD2 | |
| SCHEMBL4781653 | 0.76 | KDM4E (0.43) | NR1H2MEN1KMT2ANR1H3 | |
| SCHEMBL4781658 | 0.76 | KDM4E (0.43) | NR1H2MEN1KMT2ANR1H3 | |
| SCHEMBL4902040 | 0.76 | NR1H2 (0.38) | NR1H2MEN1KMT2ANR1H3 | |
| SCHEMBL4781505 | 0.76 | TBXA2R (0.42) | NR1H2MEN1KMT2AGRIA2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061006-A1 | SUBSTITUTED INDAN-2-YL, TETRAHYDRONAPHTHALEN-2-YL, OR DIHYDR0-2H-CHR0MEN-3-YL ARYLSULFONAMIDES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |