Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6132072 | 0.79 | TDP1 (0.42) | TDP1L3MBTL1DHFRKDM4EALDH1A1 | |
| SCHEMBL22698156 | 0.78 | — | — | |
| SCHEMBL28164503 | 0.78 | TDP1 (0.41) | TDP1L3MBTL1DHFRKDM4EALDH1A1 | |
| SCHEMBL28547139 | 0.78 | TDP1 (0.41) | TDP1L3MBTL1DHFRKDM4EALDH1A1 | |
| SCHEMBL28164575 | 0.78 | TDP1 (0.41) | TDP1L3MBTL1DHFRKDM4EALDH1A1 | |
| SCHEMBL28992711 | 0.78 | TDP1 (0.41) | TDP1L3MBTL1DHFRKDM4EALDH1A1 | |
| SCHEMBL28848032 | 0.78 | TDP1 (0.41) | TDP1L3MBTL1DHFRKDM4EALDH1A1 | |
| SCHEMBL5369216 | 0.74 | TDP1 (0.49) | TDP1L3MBTL1DHFRKDM4ERAB9A | |
| SCHEMBL4784302 | 0.74 | TLR8 (0.45) | TDP1L3MBTL1KDM4ERAB9AALDH1A1 | |
| SCHEMBL28733234 | 0.74 | TDP1 (0.38) | TDP1L3MBTL1DHFRKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042293-B9 | SUBSTITUTED PYRIDINE AND PYRIDAZINE COMPOUNDS AND THEIR PHARMACEUTICAL USE | AMGEN INC (US) | 2008-09-03 | — | — | EP | disclosed |
| EP-1042293-B1 | SUBSTITUTED PYRIDINE AND PYRIDAZINE COMPOUNDS AND THEIR PHARMACEUTICAL USE | AMGEN INC (US) | 2008-03-19 | — | — | EP | disclosed |