Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 12/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28259009 | 0.94 | TLR8 (0.44) | TLR8ALDH1A1 | |
| SCHEMBL21358990 | 0.86 | NOS2 (0.40) | TLR8KDM4ETDP1 | |
| SCHEMBL10815622 | 0.82 | TLR8 (0.36) | TLR8KDM4ERAB9ATDP1L3MBTL1 | |
| SCHEMBL6132072 | 0.79 | TDP1 (0.42) | TLR8KDM4ETDP1L3MBTL1LIPG | |
| SCHEMBL1845714 | 0.79 | TYR (0.40) | TLR8KDM4ETDP1L3MBTL1LIPG | |
| SCHEMBL28848032 | 0.78 | TDP1 (0.41) | TLR8KDM4ETDP1L3MBTL1LIPG | |
| SCHEMBL28164503 | 0.78 | TDP1 (0.41) | TLR8KDM4ETDP1L3MBTL1LIPG | |
| SCHEMBL28164575 | 0.78 | TDP1 (0.41) | TLR8KDM4ETDP1L3MBTL1LIPG | |
| SCHEMBL28547139 | 0.78 | TDP1 (0.41) | TLR8KDM4ETDP1L3MBTL1LIPG | |
| SCHEMBL28992711 | 0.78 | TDP1 (0.41) | TLR8KDM4ETDP1L3MBTL1LIPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042293-B9 | SUBSTITUTED PYRIDINE AND PYRIDAZINE COMPOUNDS AND THEIR PHARMACEUTICAL USE | AMGEN INC (US) | 2008-09-03 | — | — | EP | disclosed |
| EP-1042293-B1 | SUBSTITUTED PYRIDINE AND PYRIDAZINE COMPOUNDS AND THEIR PHARMACEUTICAL USE | AMGEN INC (US) | 2008-03-19 | — | — | EP | disclosed |