Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 19/20 | 0.54 |
| ▸ | PGR | P06401 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4784359 | 1.00 | NR3C1 (0.54) | NR3C1PGRCYP3A4CYP2C9AR | |
| SCHEMBL14144337 | 0.86 | NR3C1 (0.61) | NR3C1PGRCYP3A4CYP2C9AR | |
| SCHEMBL4738144 | 0.85 | NR3C1 (0.74) | NR3C1PGRCYP3A4CYP2C9 | |
| SCHEMBL14144304 | 0.80 | NR3C1 (0.50) | NR3C1PGR | |
| SCHEMBL14144030 | 0.79 | NR3C1 (0.49) | NR3C1PGR | |
| SCHEMBL10280277 | 0.78 | NR3C1 (0.50) | NR3C1PGR | |
| SCHEMBL14144150 | 0.78 | NR3C1 (0.49) | NR3C1PGRAR | |
| SCHEMBL14144154 | 0.77 | NR3C1 (0.47) | NR3C1PGRCYP3A4CYP2C9 | |
| SCHEMBL14144339 | 0.75 | NR3C1 (0.43) | NR3C1PGRAR | |
| SCHEMBL14144550 | 0.70 | NR3C1 (0.69) | NR3C1PGRAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008079073-A1 | INDAZOLYL SULPHONAMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS | ASTRAZENECA AB (SE) | 2008-07-03 | — | — | WO | claimed |