Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 10/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | LDLR | P01130 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4736480 | 0.90 | FASN (0.68) | FASNKMT2AMEN1POLBPRSS12 | |
| SCHEMBL4735653 | 0.89 | HSD11B1 (0.60) | FASNKMT2AMEN1ALDH1A1POLB | |
| SCHEMBL4735338 | 0.87 | FASN (0.72) | FASN | |
| SCHEMBL4734229 | 0.86 | FASN (0.54) | FASNKMT2AMEN1POLBPRSS12 | |
| SCHEMBL4735855 | 0.86 | FASN (0.57) | FASNRAB9AKMT2AMEN1NPC1 | |
| SCHEMBL4784807 | 0.86 | FASN (0.70) | FASNPRSS12 | |
| SCHEMBL4784787 | 0.85 | PRSS12 (0.55) | FASNALDH1A1POLBSMN1; SMN2PRSS12 | |
| SCHEMBL4795081 | 0.85 | FASN (0.66) | FASNPRSS12HSD11B1 | |
| SCHEMBL4737762 | 0.85 | HSD11B1 (0.57) | FASNKMT2AMEN1ALDH1A1POLB | |
| SCHEMBL4735650 | 0.84 | FASN (0.61) | FASN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008059214-A1 | BISAMLDE DERIVATIVES AND USE THEREOF AS FATTY ACID SYNTHASE INHIBITORS | ASTRAZENECA AB (SE) | 2008-05-22 | — | — | WO | claimed |
| WO-2008059214-A1 | BISAMLDE DERIVATIVES AND USE THEREOF AS FATTY ACID SYNTHASE INHIBITORS | ASTRAZENECA AB (SE) | 2008-05-22 | — | — | WO | disclosed |