Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 8/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.45 |
| ▸ | ITK | Q08881 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | BLK | P51451 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
| ▸ | STK3 | Q13188 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL877926 | 0.95 | EGFR (0.50) | ABCG2ABCB1MEN1KMT2AMAPT | |
| SCHEMBL877141 | 0.87 | EGFR (0.52) | ABCG2ABCB1MEN1KMT2AMAPT | |
| SCHEMBL876964 | 0.87 | EGFR (0.49) | ABCG2ABCB1MEN1KMT2AMAPT | |
| SCHEMBL876815 | 0.86 | ROCK2 (0.54) | ABCG2ABCB1MEN1KMT2AMAPT | |
| SCHEMBL1722294 | 0.86 | KDM1A (0.49) | ABCG2ABCB1MEN1KMT2AMAPT | |
| SCHEMBL1726552 | 0.84 | ABCG2 (0.53) | ABCG2ABCB1MEN1KMT2AMAPT | |
| SCHEMBL10218095 | 0.84 | KDM1A (0.48) | ABCG2ABCB1MEN1KMT2AMAPT | |
| SCHEMBL877253 | 0.83 | KDM1A (0.51) | ABCG2ABCB1MEN1KMT2AMAPT | |
| SCHEMBL876808 | 0.83 | EGFR (0.51) | ABCG2ABCB1MEN1KMT2AMAPT | |
| SCHEMBL3798006 | 0.83 | EGFR (0.46) | ABCG2ABCB1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008054599-A2 | RHO KINASE INHIBITORS | SURFACE LOGIX, INC. (US) | 2008-05-08 | — | — | WO | disclosed |