Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 10/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | PDE5A | O76074 | 3/20 | 0.52 |
| ▸ | KDM1A | O60341 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.49 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL876808 | 0.91 | EGFR (0.51) | ABCG2MEN1KMT2AMAPTKDM4E | |
| SCHEMBL877390 | 0.84 | MEN1 (0.50) | ABCG2MEN1KMT2AMAPTKDM4E | |
| SCHEMBL4784466 | 0.84 | ABCG2 (0.50) | ABCG2MEN1KMT2AMAPTKDM4E | |
| SCHEMBL4782453 | 0.84 | ABCG2 (0.53) | ABCG2MEN1KMT2AMAPTKDM4E | |
| SCHEMBL878154 | 0.84 | MEN1 (0.60) | ABCG2MEN1KMT2AMAPTKDM4E | |
| SCHEMBL877856 | 0.83 | ROCK2 (0.68) | ABCG2MEN1KMT2AMAPTKDM4E | |
| SCHEMBL876855 | 0.81 | ROCK2 (0.70) | ABCG2MEN1KMT2AMAPTKDM4E | |
| SCHEMBL877685 | 0.80 | JAK3 (0.53) | ABCG2MEN1KMT2AMAPTKDM4E | |
| SCHEMBL877614 | 0.80 | ABCG2 (0.68) | ABCG2MEN1KMT2AMAPTPDE5A | |
| SCHEMBL877613 | 0.80 | ABCG2 (0.68) | ABCG2MEN1KMT2AMAPTPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406236-A1 | RHO KINASE INHIBITORS | Surface Logix, Inc. (US) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010104851-A1 | RHO KINASE INHIBITORS | SURFACE LOGIX, INC. (US) | 2010-09-16 | — | — | WO | disclosed |