Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 5/20 | 0.42 |
| ▸ | APOB | P04114 | 9/20 | 0.41 |
| ▸ | MTTP | P55157 | 9/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4784618 | 0.92 | NR1H2 (0.46) | NR1H2APOBMTTPEPHX2 | |
| SCHEMBL4782179 | 0.91 | NR1H2 (0.44) | NR1H2APOBMTTPEPHX2 | |
| SCHEMBL4784068 | 0.90 | NR1H2 (0.44) | NR1H2APOBMTTPEPHX2 | |
| SCHEMBL4782985 | 0.90 | NR1H2 (0.44) | NR1H2APOBMTTPEPHX2 | |
| SCHEMBL4785575 | 0.90 | NR1H2 (0.43) | NR1H2APOBMTTPEPHX2 | |
| SCHEMBL4784895 | 0.89 | APOB (0.46) | NR1H2APOBMTTP | |
| SCHEMBL4780924 | 0.88 | NR1H2 (0.42) | NR1H2APOBMTTPEPHX2 | |
| SCHEMBL4783555 | 0.85 | NR1H2 (0.51) | NR1H2EPHX2 | |
| SCHEMBL4784693 | 0.84 | NR1H2 (0.44) | NR1H2APOBMTTPEPHX2 | |
| SCHEMBL4781106 | 0.83 | APOB (0.47) | NR1H2APOBMTTP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061006-A1 | SUBSTITUTED INDAN-2-YL, TETRAHYDRONAPHTHALEN-2-YL, OR DIHYDR0-2H-CHR0MEN-3-YL ARYLSULFONAMIDES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |