Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOB | P04114 | 10/20 | 0.46 |
| ▸ | MTTP | P55157 | 9/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.42 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.40 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.40 |
| ▸ | SFRP1 | Q8N474 | 5/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4781106 | 0.94 | APOB (0.47) | APOBMTTPNR1H2SFRP1ALOX5AP | |
| SCHEMBL4783715 | 0.91 | NR1H2 (0.46) | APOBMTTPNR1H2SFRP1FFAR1 | |
| SCHEMBL4784492 | 0.89 | NR1H2 (0.42) | APOBMTTPNR1H2 | |
| SCHEMBL4783379 | 0.89 | NR1H2 (0.43) | APOBMTTPNR1H2SFRP1ALOX5AP | |
| SCHEMBL4782467 | 0.89 | NR1H2 (0.43) | APOBMTTPNR1H2SFRP1FFAR1 | |
| SCHEMBL4783160 | 0.89 | NR1H2 (0.45) | APOBMTTPNR1H2SFRP1FFAR1 | |
| SCHEMBL4785197 | 0.87 | NR1H2 (0.45) | APOBMTTPNR1H2SFRP1FFAR1 | |
| SCHEMBL4783332 | 0.86 | NR1H2 (0.43) | APOBMTTPNR1H2SFRP1FFAR1 | |
| SCHEMBL4781127 | 0.83 | NR1H2 (0.51) | APOBMTTPNR1H2SFRP1FFAR1 | |
| SCHEMBL4784981 | 0.83 | NR1H2 (0.43) | APOBMTTPNR1H2SFRP1FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061006-A1 | SUBSTITUTED INDAN-2-YL, TETRAHYDRONAPHTHALEN-2-YL, OR DIHYDR0-2H-CHR0MEN-3-YL ARYLSULFONAMIDES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061006-A1 | SUBSTITUTED INDAN-2-YL, TETRAHYDRONAPHTHALEN-2-YL, OR DIHYDR0-2H-CHR0MEN-3-YL ARYLSULFONAMIDES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |