Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SFRP1 | Q8N474 | 7/20 | 0.53 |
| ▸ | WNT3 | P56703 | 2/20 | 0.53 |
| ▸ | BRD4 | O60885 | 4/20 | 0.43 |
| ▸ | BRD2 | P25440 | 2/20 | 0.43 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | CCR8 | P51685 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4732944 | 0.85 | SFRP1 (0.62) | SFRP1WNT3BRD4BRD2BRD3 | |
| SCHEMBL4732471 | 0.83 | SFRP1 (0.46) | SFRP1WNT3CCR8 | |
| SCHEMBL4732044 | 0.82 | SFRP1 (0.53) | SFRP1WNT3BRD4BRD2BRD3 | |
| SCHEMBL4735520 | 0.81 | SFRP1 (0.55) | SFRP1WNT3BRD4BRD2BRD3 | |
| SCHEMBL4731323 | 0.81 | SFRP1 (0.53) | SFRP1WNT3BRD4BRD2BRD3 | |
| SCHEMBL4735582 | 0.81 | SFRP1 (0.57) | SFRP1WNT3CNR2CNR1 | |
| SCHEMBL4735337 | 0.81 | SFRP1 (0.54) | SFRP1WNT3BRD4BRD2BRD3 | |
| SCHEMBL4732022 | 0.81 | SFRP1 (0.54) | SFRP1WNT3BRD4BRD2BRD3 | |
| SCHEMBL4735299 | 0.81 | SFRP1 (0.54) | SFRP1WNT3BRD4BRD2BRD3 | |
| SCHEMBL4733987 | 0.80 | SFRP1 (0.58) | SFRP1WNT3BRD4BRD2BRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061016-A1 | N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061016-A1 | N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |