Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 18/20 | 0.63 |
| ▸ | PGR | P06401 | 4/20 | 0.59 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.58 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL836751 | 0.92 | CYP11B2 (0.67) | NR3C1PGRCYP11B1CYP11B2 | |
| SCHEMBL836018 | 0.88 | NR3C1 (0.78) | NR3C1PGRCYP11B2 | |
| SCHEMBL6182232 | 0.85 | NR3C1 (0.70) | NR3C1PGRCYP11B1CYP11B2 | |
| SCHEMBL6282015 | 0.85 | CYP11B1 (0.61) | NR3C1PGRCYP11B1CYP11B2 | |
| SCHEMBL30947618 | 0.81 | CYP11B1 (0.56) | NR3C1PGRCYP11B1CYP11B2 | |
| SCHEMBL4283376 | 0.81 | NR3C1 (0.77) | NR3C1PGRCYP11B1CYP11B2 | |
| SCHEMBL27724733 | 0.80 | NR3C1 (0.60) | NR3C1PGRCYP11B1CYP11B2 | |
| SCHEMBL15505492 | 0.77 | NR3C1 (0.65) | NR3C1PGRCYP11B1CYP11B2 | |
| SCHEMBL5135413 | 0.76 | CYP11B2 (0.71) | NR3C1PGRCYP11B1CYP11B2 | |
| SCHEMBL4277681 | 0.76 | NR3C1 (0.57) | NR3C1PGRCYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008079073-A1 | INDAZOLYL SULPHONAMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS | ASTRAZENECA AB (SE) | 2008-07-03 | — | — | WO | disclosed |