Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 2/20 | 0.68 |
| ▸ | THRB | P10828 | 2/20 | 0.68 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.56 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | RXRA | P19793 | 1/20 | 0.53 |
| ▸ | RXRB | P28702 | 1/20 | 0.53 |
| ▸ | RXRG | P48443 | 1/20 | 0.53 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.52 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.50 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1171751 | 0.99 | THRA (0.70) | THRATHRBPLA2G2DALDH1A1HPGD | |
| SCHEMBL2466292 | 0.99 | THRA (0.70) | THRATHRBPLA2G2DALDH1A1HPGD | |
| SCHEMBL27669784 | 0.97 | THRA (0.65) | THRATHRBPLA2G2DALDH1A1HPGD | |
| SCHEMBL3171378 | 0.94 | THRA (0.61) | THRATHRBPLA2G2DALDH1A1HPGD | |
| SCHEMBL2593666 | 0.93 | THRA (0.59) | THRATHRBPLA2G2DALDH1A1HPGD | |
| SCHEMBL2957056 | 0.89 | THRA (0.69) | THRATHRBPLA2G2DALDH1A1HPGD | |
| SCHEMBL27754609 | 0.88 | THRA (0.74) | THRATHRBPLA2G2DALDH1A1HPGD | |
| SCHEMBL25789823 | 0.87 | PLA2G2D (0.65) | THRATHRBPLA2G2DALDH1A1HPGD | |
| SCHEMBL2582879 | 0.87 | THRA (0.54) | THRATHRBPLA2G2DALDH1A1HPGD | |
| SCHEMBL1402196 | 0.87 | TSHR (0.60) | THRATHRBPLA2G2DTSHRRXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008091967-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-31 | — | — | WO | disclosed |