Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 3/20 | 0.39 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.37 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL4785386 | 0.87 | ADRA2A (0.39) | ITGB1ADRA2ALMNAADRA2BADRA2C | |
| SCHEMBL4785359 | 0.84 | ADRA2A (0.43) | ADRA2ALMNAADRA2BADRA2CADRA1D | |
| SCHEMBL3431760 | 0.83 | ADRA2A (0.46) | ADRA2ALMNAADRA2BADRA2CADRA1D | |
| SCHEMBL4787772 | 0.82 | POLB (0.41) | ADRA2ALMNAADRA1ACYP2C9OPRK1 | |
| SCHEMBL3433804 | 0.82 | CYP2D6 (0.46) | ADRA2ALMNAADRA2BADRA2CADRA1D | |
| SCHEMBL4787684 | 0.80 | GAA (0.40) | ADRA2ALMNAADRA1ACYP2D6CYP2C9 | |
| SCHEMBL4111441 | 0.80 | WDR5 (0.45) | ADRA2ALMNAADRA2BADRA2CADRA1D | |
| SCHEMBL4111426 | 0.80 | HTR1B (0.47) | ADRA2ALMNAADRA2BADRA2CADRA1D | |
| SCHEMBL4119549 | 0.79 | ADRA2A (0.44) | ADRA2ALMNAADRA2BADRA2CADRA1D | |
| SCHEMBL3432172 | 0.78 | HTR1B (0.44) | ADRA2ALMNAADRA2BADRA2CADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008123821-A1 | 4, 5-DIHYDRO-LH-IMIDAZOL-2-AMINE DERIVATIVES FOR USE IN THE TREATMENT OF RESPIRATORY, CARDIOVASCULAR, NEUROLOGICAL OR GASTROINTESTINAL DISORDERS | ALBIREO AB (SE) | 2008-10-16 | — | — | WO | disclosed |