Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 11/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.38 |
| ▸ | EEF2K | O00418 | 1/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4785471 | 0.85 | ITGB2 (0.44) | MEN1KMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL4634246 | 0.81 | SLC16A3 (0.51) | MEN1KMT2ASLC16A3KDM4E | |
| SCHEMBL14069718 | 0.76 | HDAC3 (0.45) | MEN1KMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL4175965 | 0.75 | AKT1 (0.36) | AKT1SCN9AEEF2KDYRK3PRKD3 | |
| SCHEMBL14161493 | 0.71 | HDAC3 (0.45) | MEN1KMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL4632737 | 0.70 | KDM4E (0.50) | MEN1KMT2AKDM4EMAPT | |
| SCHEMBL3943487 | 0.70 | ROCK2 (0.38) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL4735111 | 0.69 | ITGB2 (0.56) | MEN1KMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL4632745 | 0.69 | HDAC3 (0.45) | MEN1KMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL4632690 | 0.68 | HDAC3 (0.44) | MEN1KMT2AHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008071453-A1 | 1,2-DIARYLACETYLENE DERIVATIVES OF ACYLTRYPTOPHANOLS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-06-19 | — | — | WO | claimed |
| WO-2008071453-A1 | 1,2-DIARYLACETYLENE DERIVATIVES OF ACYLTRYPTOPHANOLS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-06-19 | — | — | WO | disclosed |