Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 16/20 | 0.48 |
| ▸ | HCRTR2 | O43614 | 13/20 | 0.48 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 2/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4785253 | 0.88 | HCRTR1 (0.52) | HCRTR1HCRTR2 | |
| SCHEMBL3060001 | 0.85 | HCRTR1 (0.53) | HCRTR1HCRTR2 | |
| SCHEMBL3067509 | 0.77 | HCRTR1 (0.47) | HCRTR1HCRTR2 | |
| SCHEMBL4786332 | 0.77 | HCRTR1 (0.51) | HCRTR1HCRTR2 | |
| SCHEMBL1398890 | 0.77 | HCRTR1 (0.55) | HCRTR1HCRTR2 | |
| SCHEMBL3312180 | 0.74 | HCRTR1 (0.45) | HCRTR1HCRTR2 | |
| SCHEMBL4787101 | 0.74 | HCRTR1 (0.70) | HCRTR1HCRTR2 | |
| SCHEMBL15174181 | 0.73 | HCRTR1 (0.73) | HCRTR1HCRTR2 | |
| SCHEMBL1599349 | 0.73 | HCRTR1 (0.67) | HCRTR1HCRTR2 | |
| SCHEMBL1599350 | 0.73 | HCRTR1 (0.67) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008087611-A2 | PYRROLIDINE- AND PIPERIDINE- BIS-AMIDE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2008-07-24 | — | — | WO | claimed |
| WO-2008087611-A2 | PYRROLIDINE- AND PIPERIDINE- BIS-AMIDE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2008-07-24 | — | — | WO | disclosed |