Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 2/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | MYC | P01106 | 1/20 | 0.38 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.38 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4789331 | 0.89 | ADORA1 (0.51) | ADORA1GPR119HDAC1HDAC6MAPT | |
| SCHEMBL4788162 | 0.82 | HDAC1 (0.56) | ADORA1GPR119HDAC1HDAC6ESR2 | |
| SCHEMBL5107551 | 0.81 | HDAC1 (0.57) | ADORA1GPR119HDAC1HDAC6ESR2 | |
| SCHEMBL31078485 | 0.81 | HDAC1 (0.57) | ADORA1GPR119HDAC1HDAC6ESR2 | |
| SCHEMBL4786111 | 0.77 | GPR119 (0.46) | ADORA1GPR119HDAC1HDAC6ESR2 | |
| SCHEMBL28603644 | 0.76 | BAZ2B (0.51) | GPR119HDAC1HDAC6ESR2GRM5 | |
| SCHEMBL5114861 | 0.76 | PTGDR2 (0.49) | HDAC1HDAC6GRM5GRM1HPGDS | |
| SCHEMBL968966 | 0.74 | HDAC1 (0.50) | ADORA1GPR119HDAC1HDAC6ESR2 | |
| SCHEMBL4789515 | 0.73 | MAP3K14 (0.45) | ADORA1GPR119HDAC1HDAC6ESR2 | |
| SCHEMBL28602906 | 0.73 | HDAC1 (0.54) | HDAC1HDAC6ESR2GRM5GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008134354-A1 | TNF-α PRODUCTION INHIBITOR | ARRAY BIOPHARMA, INC. (US) | 2008-11-06 | — | — | WO | disclosed |