Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 3/20 | 0.51 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4786115 | 0.89 | ADORA1 (0.47) | ADORA1ALDH1A1MAPTKDM4EHDAC1 | |
| SCHEMBL12602495 | 0.80 | ALDH1A1 (0.47) | ADORA1KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL5107551 | 0.77 | HDAC1 (0.57) | ADORA1HDAC1HDAC6GPR119 | |
| SCHEMBL31078485 | 0.77 | HDAC1 (0.57) | ADORA1HDAC1HDAC6GPR119 | |
| SCHEMBL22558480 | 0.74 | ALDH1A1 (0.46) | ADORA1KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL18618371 | 0.74 | ADORA1 (0.44) | ADORA1KMT2AMEN1HDAC1HDAC6 | |
| SCHEMBL4788162 | 0.73 | HDAC1 (0.56) | ADORA1ARHDAC1HDAC6GAA | |
| SCHEMBL2240101 | 0.72 | CHRM5 (0.61) | ADORA1 | |
| SCHEMBL20558294 | 0.72 | ADORA1 (0.51) | ADORA1KMT2AMEN1ALDH1A1GAA | |
| SCHEMBL30670170 | 0.72 | ADORA1 (0.51) | ADORA1KMT2AMEN1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008134354-A1 | TNF-α PRODUCTION INHIBITOR | ARRAY BIOPHARMA, INC. (US) | 2008-11-06 | — | — | WO | disclosed |