Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Carbazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | GPR3 | P46089 | 2/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.58 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | AHR | P35869 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KIF11 | P52732 | 2/20 | 0.53 |
| ▸ | GABRP | O00591 | 1/20 | 0.53 |
| ▸ | GABRD | O14764 | 1/20 | 0.53 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbazole SCHEMBL30528395 | 1.00 | ALDH1A1 (0.67) | ALDH1A1GPR3HSD17B10KDM4EKMT2A | |
| Carbazole SCHEMBL28171971 | 0.93 | ALDH1A1 (0.70) | ALDH1A1GPR3HSD17B10KDM4EKMT2A | |
| Carbazole SCHEMBL8411559 | 0.90 | ALDH1A1 (0.74) | ALDH1A1GPR3HSD17B10KDM4EKMT2A | |
| Acridone SCHEMBL10322225 | 0.89 | KDM4E (0.75) | ALDH1A1GPR3HSD17B10KDM4EKMT2A | |
| Carbazole SCHEMBL27705422 | 0.88 | ALDH1A1 (0.64) | ALDH1A1GPR3HSD17B10KDM4EKMT2A | |
| Carbazole SCHEMBL28478007 | 0.88 | ALDH1A1 (0.64) | ALDH1A1GPR3HSD17B10KDM4EKMT2A | |
| Carbazole SCHEMBL28153769 | 0.87 | ALDH1A1 (0.56) | ALDH1A1GPR3HSD17B10KDM4EKMT2A | |
| Carbazole SCHEMBL252614 | 0.87 | ALDH1A1 (0.56) | ALDH1A1GPR3HSD17B10KDM4EKMT2A | |
| Carbazole SCHEMBL9576655 | 0.86 | ALDH1A1 (0.61) | ALDH1A1GPR3HSD17B10KDM4EKMT2A | |
| Carbazole SCHEMBL28048441 | 0.85 | ALDH1A1 (0.82) | ALDH1A1GPR3HSD17B10KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101157650-B | Method for preparation of indole-1-methyl formate and its derivatives | UNIV EAST CHINA NORMAL | 2011-04-27 | — | — | CN | claimed |
| CN-119521932-A | Near-infrared organic photoelectric detector based on carbazole derivative and application thereof | 华南理工大学 | 2025-02-25 | — | — | CN | disclosed |
| US-20240099955-A1 | SKINCARE COMPOSITIONS AND METHODS OF USE THEREOF | HTL BIOTECHNOLOGY INNOVATION INC. | 2024-03-28 | — | — | US | disclosed |
| EP-4288084-A1 | SKINCARE COMPOSITIONS AND METHODS OF USE THEREOF | Modern Meadow, Inc. (US) | 2023-12-13 | — | — | EP | disclosed |
| CN-116847871-A | Skin care compositions and methods of use | 现代牧场股份有限公司 | 2023-10-03 | — | — | CN | disclosed |
| CN-115397466-A | Novel 3,5-diaminobenzoic acid-based compound, pin1 inhibitor using same, and therapeutic agent for inflammatory disease | 国立大学法人广岛大学 | 2022-11-25 | — | — | CN | disclosed |
| WO-2022170114-A1 | SKINCARE COMPOSITIONS AND METHODS OF USE THEREOF | MODERN MEADOW, INC. (US) | 2022-08-11 | — | — | WO | disclosed |
| EP-3398585-B1 | EXTERNAL DERMAL COMPOSITION FOR ANTI-AGEING AND METHOD FOR PRODUCING THE SAME | HAYASHIBARA CO (JP) | 2020-02-26 | — | — | EP | disclosed |
| US-20190008747-A1 | EXTERNAL DERMAL COMPOSITION FOR ANTI-AGEING AND METHOD FOR PRODUCING THE SAME | Hayashibara Co., Ltd. (JP) | 2019-01-10 | — | — | US | disclosed |
| EP-3398585-A1 | EXTERNAL DERMAL COMPOSITION FOR ANTI-AGEING AND METHOD FOR PRODUCING THE SAME | Hayashibara Co., Ltd. (JP) | 2018-11-07 | — | — | EP | disclosed |
| US-20030212123-A1 | COX-2 selective carprofen for treating pain and inflammation in dogs | PFIZER INC. | 2003-11-13 | — | — | US | disclosed |
| EP-0988034-A1 | COX-2 SELECTIVE CARPROFEN FOR TREATING PAIN AND INFLAMMATION IN DOGS | PFIZER INC. (US) | 2000-03-29 | — | — | EP | disclosed |
| WO-1998050033-A1 | COX-2 SELECTIVE CARPROFEN FOR TREATING PAIN AND INFLAMMATION IN DOGS | PFIZER INC. (US) | 1998-11-12 | — | — | WO | disclosed |
| US-5071868-A | Beta blockers, vasodilators, therapy for glaucoma | BOEHRINGER MANNHEIM GMBH (DE) | 1991-12-10 | — | — | US | disclosed |
| US-4985454-A | TREATMENT OF GLAUCOMA | BOEHRINGER MANNHEIM GMBH (DE) | 1991-01-15 | — | — | US | disclosed |
| US-4824963-A | REACTING EPICHLOROHYDRIN WITH 4-HYDROOXYCARBAZOLE, AMINATION | BOEHRINGER MANNHEIM GMBH (DE) | 1989-04-25 | — | — | US | disclosed |
| US-4697022-A | Process for the preparation of optically-active carbazole derivatives, new R- and S-carbazole derivatives and pharmaceutical compositions containing these compounds | BOEHRINGER MANNHEIM GMBH (DE) | 1987-09-29 | — | — | US | disclosed |
| US-4234487-A | Process of making a carbazole acetic acid | HOFFMANN-LA ROCHE INC. (US) | 1980-11-18 | — | — | US | disclosed |
| US-4178289-A | Carbazole acetic acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 1979-12-11 | — | — | US | disclosed |
| US-4057559-A | ANTIINFLAMMATORY AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1977-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030212123-A1 | COX-2 selective carprofen for treating pain and inflammation in dogs | PTGES2, PTGER2, PTGS2 | ALDH1A1 132/4885GPR3 381/4885HSD17B10 325/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.