Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 3/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | CMA1 | P23946 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9835971 | 0.86 | POLB (0.41) | DRD2SLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL7412400 | 0.77 | DRD2 (0.36) | DRD2SLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL10305227 | 0.75 | CREBBP (0.40) | DRD2SLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL18289479 | 0.74 | AHR (0.50) | DRD2ADRA1ADRD4DRD3AHR | |
| SCHEMBL13222379 | 0.72 | DRD2 (0.42) | DRD2SLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL13243255 | 0.72 | DRD2 (0.42) | DRD2SLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL8122818 | 0.72 | DRD2 (0.42) | DRD2SLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL3026960 | 0.72 | DRD2 (0.42) | DRD2SLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL3032145 | 0.72 | DRD2 (0.42) | DRD2SLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL3032121 | 0.72 | DRD2 (0.42) | DRD2SLC6A4ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008118935-A1 | COMPOUNDS AND PROCESSES FOR PREPARING SUBSTITUTED AMINOMETHYL-2,3,8,9-TETRAHYDRO-7H-1,4-DIOXINO[2,3-E]INDOL-8-ONES | NEUROGEN CORPORATION (US) | 2008-10-02 | — | — | WO | disclosed |
| EP-0932609-B1 | AZAHETEROCYCLYMETHYL DERIVATIVES OF 2,3,8,9-TETRAHYDRO-7H-1,4-DIOXINO 2,3-e]INDOL-8-ONE | WYETH CORP (US) | 2003-05-14 | — | — | EP | disclosed |
| EP-0932609-A1 | AZAHETEROCYCLYMETHYL DERIVATIVES OF 2,3,8,9-TETRAHYDRO-7H-1,4-DIOXINO 2,3-e]INDOL-8-ONE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-08-04 | — | — | EP | disclosed |
| WO-1998016530-A1 | AZAHETEROCYCLYMETHYL DERIVATIVES OF 2,3,8,9-TETRAHYDRO-7H-1,4-DIOXINO[2,3-e]INDOL-8-ONE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-04-23 | — | — | WO | disclosed |