Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 6/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.36 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.36 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4786408 | 0.86 | DRD2 (0.37) | DRD2ADRA1AADRA1DSLC6A4ADRA1B | |
| SCHEMBL7412400 | 0.77 | DRD2 (0.36) | LMNAGSK3BDRD2ADRA1AADRA1D | |
| SCHEMBL10305227 | 0.75 | CREBBP (0.40) | DRD2ADRA1AADRA1DSLC6A4ADRA1B | |
| SCHEMBL18289479 | 0.74 | AHR (0.50) | LMNAGSK3BDRD2ADRA1ADRD4 | |
| SCHEMBL7478754 | 0.72 | AHR (0.42) | POLBMAPTHSD17B10NQO2GSK3B | |
| SCHEMBL13222379 | 0.72 | DRD2 (0.42) | LMNADRD2ADRA1AADRA1DSLC6A4 | |
| SCHEMBL13243255 | 0.72 | DRD2 (0.42) | DRD2ADRA1AADRA1DSLC6A4ADRA1B | |
| SCHEMBL3032145 | 0.72 | DRD2 (0.42) | DRD2ADRA1AADRA1DSLC6A4ADRA1B | |
| SCHEMBL8122818 | 0.72 | DRD2 (0.42) | DRD2ADRA1AADRA1DSLC6A4ADRA1B | |
| SCHEMBL3026960 | 0.72 | DRD2 (0.42) | DRD2ADRA1AADRA1DSLC6A4ADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0208510-B1 | 1-SUBSTITUTED OXINDOLE-3-CARBOXAMINES AS ANTIINFLAMMATORY AND ANALGESIC AGENTS | PFIZER INC. (US) | 1991-09-11 | — | — | EP | disclosed |
| US-4791129-A | RHEUMATIC DISEASES; ANTIARTHRITIC AGENTS | PFIZER INC. (US) | 1988-12-13 | — | — | US | disclosed |
| US-4725616-A | ANTIARTHRITIC AGENTS | PFIZER INC. (US) | 1988-02-16 | — | — | US | disclosed |