Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4785482 | 0.84 | DPP7 (0.36) | CYP2C19SMN1; SMN2ALDH1A1TDP1HTT | |
| SCHEMBL28672211 | 0.81 | L3MBTL1 (0.42) | CYP3A4CYP2C19SMN1; SMN2GLAALDH1A1 | |
| SCHEMBL8488986 | 0.77 | CYP3A4 (0.47) | CYP3A4CYP2C19SMN1; SMN2POLBLMNA | |
| SCHEMBL5482918 | 0.77 | CYP3A4 (0.47) | CYP3A4CYP2C19SMN1; SMN2POLBLMNA | |
| SCHEMBL4758016 | 0.75 | CYP3A4 (0.47) | CYP3A4CYP2C19SMN1; SMN2POLBGLA | |
| SCHEMBL4758007 | 0.75 | CYP3A4 (0.47) | CYP3A4CYP2C19SMN1; SMN2POLBGLA | |
| SCHEMBL3056306 | 0.74 | CYP3A4 (0.41) | CYP3A4CYP2C19SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL16964809 | 0.74 | CYP3A4 (0.41) | CYP3A4CYP2C19SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL8483745 | 0.73 | CYP3A4 (0.50) | CYP3A4CYP2C19SMN1; SMN2POLBLMNA | |
| SCHEMBL12196226 | 0.73 | CYP3A4 (0.50) | CYP3A4CYP2C19SMN1; SMN2POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124582-A1 | RENIN INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-16 | — | — | WO | disclosed |