Citric Acid

Citric Acid

SCHEMBL47868

O=C(O)CC(O)(CC(=O)O)C(=O)O.[KH]

nearest known ligand 0.94

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2

The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 1/20 0.41
ALDH1A1 P00352 2/20 0.94
HMGCR P04035 1/20 0.48
CHRM1 P11229 1/20 0.48
TBXA2R P21731 1/20 0.48
ADRA1A P35348 1/20 0.48
TSHR P16473 2/20 0.46
CYP2D6 P10635 2/20 0.46
CYP2C19 P33261 1/20 0.46
HIF1A Q16665 1/20 0.46
ACLY P53396 4/20 0.44
KDM4E B2RXH2 2/20 0.43
LMNA P02545 2/20 0.43
MAPT P10636 1/20 0.43
ALOX15 P16050 1/20 0.43
SLC13A5 Q86YT5 4/20 0.42
CPT2 P23786 1/20 0.42
CYP1A2 P05177 1/20 0.41
KMT2A Q03164 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Citric Acid SCHEMBL8973204 1.00 ALDH1A1 (0.94) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL316826 1.00 ALDH1A1 (0.94) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL5515900 1.00 ALDH1A1 (0.94) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL10751372 1.00 ALDH1A1 (0.94) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL4009914 1.00 ALDH1A1 (0.94) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL676375 1.00 ALDH1A1 (0.94) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL25190736 0.97 ALDH1A1 (0.88) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL16345363 0.97 ALDH1A1 (0.88) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL1135947 0.97 ALDH1A1 (0.88) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL372319 0.97 ALDH1A1 (0.88) ALDH1A1HMGCRCHRM1TBXA2RADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 66730 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260144725-A1 TOOTH DESENSITIZING ORAL CARE COMPOSITIONS, DEVICES, AND METHODS THE PROCTER & GAMBLE COMPANY (US) 2026-05-28 US claimed
EP-4746864-A1 C5 KETONE COMPOSITIONS AND RELATED METHODS FOR TREATING METABOLIC DYSFUNCTION Keto Innovations, LLC (US) 2026-05-27 EP claimed
EP-4401569-B1 BULK MELT-TO-MAKE PECTIN-BASED GUMMY MIX PRECURSOR AND METHODS OF MAKING AND USING M2M GUMMIES LLC (US) 2026-05-27 EP claimed
EP-3836899-B1 CHEMOTHERAPEUTIC PHARMACEUTICAL SUSPENSION FOR ORAL DOSAGE ONCOSOL LTD (GB) 2026-05-27 EP claimed
CN-116553684-B Device and method for electrochemical oxidation total denitrification of ammonia nitrogen wastewater EAST CHINA JIAOTONG UNIVERSITY (CN) 2026-05-26 CN claimed
CN-121369665-B Delicious peptide-based low-salt thick broad-bean sauce and production process thereof Sichuan Dandan Pixian Bean Paste Group Co.,Ltd. (CN) 2026-05-26 CN claimed
CN-122094704-A Formulations for oral administration of active agents comprising a combination of acid-neutralizing polymer and non-polymeric material 2026-05-26 CN claimed
CN-122074633-A Flavour composition, aqueous food composition containing said flavour composition, preparation and use thereof 2026-05-26 CN claimed
CN-121873800-B Alkali polishing additive, polishing solution and polishing method Jiageng Innovation Laboratory (CN) 2026-05-26 CN claimed
CN-122074562-A Jam inner core for cheese food and preparation method thereof 2026-05-26 CN claimed
US-3994729-A DIALDEHYDES, FIXING WITH THIOSULFATES, ALUMINUM SALT, TARTARIC ACID OR CITRIC ACID FUJI PHOTO FILM CO., LTD. (JA) 1976-11-30 US claimed
US-3983252-A Stable dialdehyde-containing disinfectant compositions and methods BUCHALTER GILBERT 1976-09-28 US claimed
US-3982025-A Soy cheese spread and process for preparing same FUJI OIL COMPANY, LTD. (JA) 1976-09-21 US claimed
US-3973074-A POTASSIUM HYDROXIDE OR CARBONATE MACMILLAN BLOEDEL LIMITED (CA) 1976-08-03 US claimed
US-3968263-A CALCIUM PHOSPHATE GENERAL FOODS CORPORATION (US) 1976-07-06 US claimed
US-3964255-A Method of inflating an automobile passenger restraint bag SPECIALTY PRODUCTS DEVELOPMENT CORPORATION (US) 1976-06-22 US claimed
US-3962482-A Clear, elastic, water gels based on carrageenan UNIROYAL, LTD. (CA) 1976-06-08 US claimed
US-3941723-A Crystallized alkali metal silicate with sequestering agents PHILADELPHIA QUARTZ COMPANY (US) 1976-03-02 US claimed
US-3935323-A CHEESE WHEY STAUFFER CHEMICAL COMPANY (US) 1976-01-27 US claimed
US-3932655-A CHELATING AGENTS, N-ALKYL BENZALKONIUM CHLORIDES INTERNATIONAL PHARMAKON LABORATORIES, INC. (US) 1976-01-13 US claimed