Citric Acid

Citric Acid

SCHEMBL676375

O=C(O)CC(O)(CC(=O)O)C(=O)O.[KH].[KH].[KH]

nearest known ligand 0.94

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2

The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 1/20 0.41
ALDH1A1 P00352 2/20 0.94
HMGCR P04035 1/20 0.48
CHRM1 P11229 1/20 0.48
TBXA2R P21731 1/20 0.48
ADRA1A P35348 1/20 0.48
TSHR P16473 2/20 0.46
CYP2D6 P10635 2/20 0.46
CYP2C19 P33261 1/20 0.46
HIF1A Q16665 1/20 0.46
ACLY P53396 4/20 0.44
KDM4E B2RXH2 2/20 0.43
LMNA P02545 2/20 0.43
MAPT P10636 1/20 0.43
ALOX15 P16050 1/20 0.43
SLC13A5 Q86YT5 4/20 0.42
CPT2 P23786 1/20 0.42
CYP1A2 P05177 1/20 0.41
KMT2A Q03164 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Citric Acid SCHEMBL8973204 1.00 ALDH1A1 (0.94) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL316826 1.00 ALDH1A1 (0.94) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL5515900 1.00 ALDH1A1 (0.94) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL10751372 1.00 ALDH1A1 (0.94) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL47868 1.00 ALDH1A1 (0.94) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL4009914 1.00 ALDH1A1 (0.94) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL25190736 0.97 ALDH1A1 (0.88) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL16345363 0.97 ALDH1A1 (0.88) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL1135947 0.97 ALDH1A1 (0.88) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL372319 0.97 ALDH1A1 (0.88) ALDH1A1HMGCRCHRM1TBXA2RADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 167 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116060013-A Method for preparing carbon-coated bimetallic hydrogenation catalyst through hydrothermal carbonization 中国科学院兰州化学物理研究所 2023-05-05 CN claimed
US-20200354847-A1 COMPOSITIONALLY MODULATED ZINC-IRON MULTILAYERED COATINGS THE BOEING COMPANY 2020-11-12 US claimed
CN-104911128-B A kind of thermophilic anaerobic bacillus and its application in production lactic acid 华南理工大学 2019-01-29 CN claimed
US-20180355497-A1 COMPOSITIONALLY MODULATED ZINC-IRON MULTILAYERED COATINGS THE BOEING COMPANY 2018-12-13 US claimed
EP-3412799-A1 COMPOSITIONALLY MODULATED ZINC-IRON MULTILAYERED COATINGS The Boeing Company (US) 2018-12-12 EP claimed
US-10117971-B2 Antimicrobial compositions and methods for locking catheters BECTON, DICKINSON AND COMPANY (US) 2018-11-06 US claimed
US-20180126044-A1 Antimicrobial Compositions and Methods for Locking Catheters BECTON, DICKINSON AND COMPANY 2018-05-10 US claimed
US-9872941-B2 Antimicrobial compositions and methods for locking catheters BECTON, DICKINSON AND COMPANY (US) 2018-01-23 US claimed
EP-3263145-A1 ANTIMICROBIAL COMPOSITIONS AND METHODS FOR LOCKING CATHETERS Becton, Dickinson and Company (US) 2018-01-03 EP claimed
EP-2391632-B1 BACTERIOSTATIC CATHETER LOCK CONTAINING GLYCEROL TELEFLEX MEDICAL INC (US) 2017-11-15 EP claimed
EP-2012599-B1 CALCIUM ENRICHMENT COMPOSITIONS METHOD OF PRODUCTION THEREOF AND USE GADOT BIOCHEMICAL IND LTD (IL) 2010-04-28 EP claimed
WO-2009147667-A1 PRODUCTION OF POTASSIUM MAGNESIUM CITRATE AND ITS APPLICATIONS GADOT BIOCHEMICAL INDUSTRIES LTD. (IL) 2009-12-10 WO claimed
JP-2009528360-A 2009-08-06 JP claimed
US-20090142451-A1 Calcium Enrichment Compositions Method of Production Thereof and Use GADOT BIOCHEMICAL INDUSTRIES LTD (IL) 2009-06-04 US claimed
EP-1998825-A2 ANTIMICROBIAL COMPOSITIONS AND METHODS FOR LOCKING CATHETERS Becton, Dickinson and Company, Wagner, Jaconda (US) 2008-12-10 EP claimed
WO-2007100776-A2 ANTIMICROBIAL COMPOSITIONS AND METHODS FOR LOCKING CATHETERS BECTON, DICKINSON AND COMPANY (US) 2007-09-07 WO claimed
US-20070202177-A1 Antimicrobial Compositions and Methods for Locking Catheters BECTON, DICKINSON AND COMPANY (US) 2007-08-30 US claimed
EP-1245247-A1 Biocidal locks Biolink Corporation (US) 2002-10-02 EP claimed
US-6350251-B1 Biocidal locks BIOLINK CORPORATION 2002-02-26 US claimed
US-5500668-A INK JET PRINTING XEROX CORPORATION (US) 1996-03-19 US claimed