Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.49 |
| ▸ | DHFR | P00374 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4788964 | 0.90 | MAPT (0.50) | MAPTCSNK2A1DHFRALDH1A1KMT2A | |
| SCHEMBL4788538 | 0.89 | MAPT (0.60) | MAPTDHFRALDH1A1RXFP1MEN1 | |
| SCHEMBL4788288 | 0.79 | DHFR (0.52) | MAPTCSNK2A1DHFRALDH1A1MEN1 | |
| SCHEMBL1689007 | 0.79 | MAPT (0.64) | MAPTDHFRALDH1A1RXFP1MEN1 | |
| SCHEMBL12088423 | 0.79 | MAPT (0.64) | MAPTDHFRALDH1A1RXFP1GAA | |
| SCHEMBL14021034 | 0.78 | DHFR (0.51) | MAPTCSNK2A1DHFRALDH1A1RXFP1 | |
| SCHEMBL14020392 | 0.77 | CSNK2A1 (0.44) | MAPTCSNK2A1ALDH1A1MEN1KMT2A | |
| SCHEMBL1689034 | 0.76 | MAPT (0.61) | MAPTDHFRALDH1A1RXFP1GAA | |
| SCHEMBL1753211 | 0.76 | MAPT (1.00) | MAPTALDH1A1NPSR1LMNATP53 | |
| SCHEMBL1689171 | 0.76 | MAPT (0.61) | MAPTDHFRALDH1A1RXFP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008134300-A1 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY | IRM LLC (BM) | 2008-11-06 | — | — | WO | claimed |
| WO-2008134300-A1 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY | IRM LLC (BM) | 2008-11-06 | — | — | WO | disclosed |
| WO-2008134300-A1 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY | IRM LLC (BM) | 2008-11-06 | — | — | WO | disclosed |