Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 18/20 | 1.00 |
| ▸ | EGFR | P00533 | 16/20 | 1.00 |
| ▸ | ABL1 | P00519 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4788703 | 0.94 | BRAF (0.89) | BRAFEGFRABL1 | |
| SCHEMBL4787314 | 0.92 | BRAF (0.85) | BRAFEGFRABL1 | |
| SCHEMBL4788543 | 0.89 | BRAF (0.80) | BRAFEGFRABL1 | |
| SCHEMBL2289051 | 0.87 | BRAF (0.77) | BRAFEGFRABL1 | |
| SCHEMBL13708173 | 0.87 | BRAF (0.76) | BRAFEGFRABL1 | |
| SCHEMBL17208714 | 0.86 | BRAF (0.76) | BRAFEGFR | |
| SCHEMBL31620739 | 0.85 | BRAF (0.86) | BRAFEGFR | |
| SCHEMBL12518524 | 0.85 | BRAF (0.74) | BRAFEGFRABL1 | |
| SCHEMBL4788539 | 0.85 | BRAF (0.74) | BRAFEGFRABL1 | |
| SCHEMBL4789778 | 0.85 | EGFR (0.88) | BRAFEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | claimed |
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |