Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 17/20 | 0.85 |
| ▸ | EGFR | P00533 | 15/20 | 0.85 |
| ▸ | ABL1 | P00519 | 2/20 | 0.64 |
| ▸ | BCR | P11274 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4788543 | 0.97 | BRAF (0.80) | BRAFEGFRABL1BCR | |
| SCHEMBL4788539 | 0.93 | BRAF (0.74) | BRAFEGFRABL1BCR | |
| SCHEMBL4788703 | 0.92 | BRAF (0.89) | BRAFEGFRABL1 | |
| SCHEMBL4786842 | 0.92 | BRAF (1.00) | BRAFEGFRABL1 | |
| SCHEMBL4788876 | 0.86 | ATM (0.67) | BRAFEGFRABL1 | |
| SCHEMBL4789778 | 0.83 | EGFR (0.88) | BRAFEGFR | |
| SCHEMBL13878777 | 0.81 | BRAF (0.66) | BRAFEGFR | |
| SCHEMBL13708183 | 0.81 | BRAF (0.67) | BRAFEGFRABL1BCR | |
| SCHEMBL13878776 | 0.79 | BRAF (0.67) | BRAFEGFR | |
| SCHEMBL2289051 | 0.79 | BRAF (0.77) | BRAFEGFRABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | claimed |
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |