Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.88 |
| ▸ | BRAF | P15056 | 7/20 | 0.88 |
| ▸ | HTT | P42858 | 3/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.70 |
| ▸ | ATM | Q13315 | 1/20 | 0.70 |
| ▸ | HCK | P08631 | 2/20 | 0.68 |
| ▸ | BTK | Q06187 | 2/20 | 0.68 |
| ▸ | CLK1 | P49759 | 1/20 | 0.66 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4788703 | 0.91 | BRAF (0.89) | EGFRBRAFHTTMAPK1ATM | |
| SCHEMBL4786842 | 0.85 | BRAF (1.00) | EGFRBRAF | |
| SCHEMBL13878758 | 0.83 | HTT (0.74) | EGFRBRAFHTTMAPK1ATM | |
| SCHEMBL4787314 | 0.83 | BRAF (0.85) | EGFRBRAF | |
| SCHEMBL13878755 | 0.82 | HTT (0.69) | EGFRBRAFHTTMAPK1ATM | |
| SCHEMBL13708167 | 0.82 | ATM (0.69) | EGFRBRAFHTTMAPK1ATM | |
| SCHEMBL4789121 | 0.81 | ATM (0.79) | EGFRBRAFHTTMAPK1ATM | |
| SCHEMBL16236899 | 0.81 | KIT (0.86) | EGFRBRAFHTTMAPK1ATM | |
| SCHEMBL14704592 | 0.81 | MAPK14 (0.78) | EGFRBRAFHTTMAPK1ATM | |
| SCHEMBL16810176 | 0.81 | BTK (1.00) | EGFRBRAFHTTMAPK1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | claimed |
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |