Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SI | P14410 | 1/20 | 0.47 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.47 |
| ▸ | AGPAT2 | O15120 | 5/20 | 0.46 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.43 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4286785 | 0.89 | RECQL (0.53) | AGPAT2ALDH1A1LMNAHSP90AA1HSP90AB1 | |
| SCHEMBL4738127 | 0.78 | AGPAT2 (0.48) | MGAMGAASIMGAM2AGPAT2 | |
| SCHEMBL9566435 | 0.76 | MGAM (0.54) | MGAMGAASIMGAM2AGPAT2 | |
| SCHEMBL3952206 | 0.76 | HSP90AA1 (0.68) | MGAMGAASIMGAM2AGPAT2 | |
| SCHEMBL4284941 | 0.73 | RECQL (0.54) | AGPAT2ALDH1A1LMNAHSP90AA1HSP90AB1 | |
| SCHEMBL31060657 | 0.73 | MGAM (0.42) | MGAMGAASIMGAM2AGPAT2 | |
| SCHEMBL14125145 | 0.71 | GAA (0.56) | MGAMGAASIMGAM2AMY1A | |
| SCHEMBL27631530 | 0.70 | ADORA1 (0.50) | MAPK1RECQLADORA2AADORA1L3MBTL1 | |
| SCHEMBL13678704 | 0.69 | ALDH1A1 (0.43) | MGAMGAASIMGAM2AGPAT2 | |
| SCHEMBL3325452 | 0.69 | AGPAT2 (0.46) | MGAMGAASIMGAM2AGPAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008074445-A1 | NOVEL TRICYCLIC AND HETEROTRICYCLIC DERIVATIVES, PROCESSES FOR PREPARING THEM, PHARMACEUTICAL COMPOSITIONS THEREOF | UCB PHARMA, S.A. (BE) | 2008-06-26 | — | — | WO | claimed |
| WO-2008074445-A1 | NOVEL TRICYCLIC AND HETEROTRICYCLIC DERIVATIVES, PROCESSES FOR PREPARING THEM, PHARMACEUTICAL COMPOSITIONS THEREOF | UCB PHARMA, S.A. (BE) | 2008-06-26 | — | — | WO | disclosed |