Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 9/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.55 |
| ▸ | MMP3 | P08254 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HPGDS | O60760 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6359855 | 0.88 | DYRK1A (0.51) | HDAC1HDAC8HDAC6DYRK1ADYRK1B | |
| SCHEMBL4677903 | 0.84 | HPGD (0.61) | RAB9AKDM4EALDH1A1HPGDHPGDS | |
| SCHEMBL7235823 | 0.83 | HPGD (0.44) | HDAC1HDAC8HDAC6DYRK1ADYRK1B | |
| SCHEMBL7236771 | 0.80 | KDM4E (0.51) | NPC1RAB9AKDM4EALDH1A1HPGD | |
| SCHEMBL5903684 | 0.76 | HDAC1 (1.00) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL6353641 | 0.76 | CDC25B (0.50) | HDAC1HDAC6HDAC3HDAC4NPC1 | |
| SCHEMBL13707355 | 0.75 | CA12 (0.47) | KDM4EALDH1A1HPGD | |
| SCHEMBL6361898 | 0.75 | HPGDS (0.43) | HDAC1HDAC6HDAC3DYRK1ADYRK1B | |
| SCHEMBL1890491 | 0.72 | HDAC8 (0.64) | HDAC1HDAC8HDAC6MMP3HDAC3 | |
| SCHEMBL29355433 | 0.71 | HDAC6 (1.00) | HDAC1HDAC8HDAC6MMP3HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008101186-A1 | INHIBITORS FOR HDAC8 | THE J. DAVID GLADSTONE INSTITUTES (US) | 2008-08-21 | — | — | WO | disclosed |
| WO-2008101186-A1 | INHIBITORS FOR HDAC8 | THE J. DAVID GLADSTONE INSTITUTES (US) | 2008-08-21 | — | — | WO | disclosed |