Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 10/20 | 0.51 |
| ▸ | DYRK1B | Q9Y463 | 10/20 | 0.51 |
| ▸ | HPGDS | O60760 | 2/20 | 0.47 |
| ▸ | PRP4K | Q13523 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.43 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.43 |
| ▸ | ESRRG | P62508 | 3/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4787012 | 0.88 | HDAC1 (0.61) | DYRK1ADYRK1BHPGDSHDAC1NPC1 | |
| SCHEMBL4677903 | 0.81 | HPGD (0.61) | HPGDSRAB9AKDM4EALDH1A1HPGD | |
| SCHEMBL7235823 | 0.80 | HPGD (0.44) | DYRK1ADYRK1BHPGDSHDAC1RAB9A | |
| SCHEMBL7236771 | 0.78 | KDM4E (0.51) | NPC1RAB9AKDM4EALDH1A1HPGD | |
| SCHEMBL6361898 | 0.78 | HPGDS (0.43) | DYRK1ADYRK1BHPGDSPRP4KHDAC1 | |
| SCHEMBL6353641 | 0.76 | CDC25B (0.50) | HDAC1NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL13707355 | 0.73 | CA12 (0.47) | KDM4EALDH1A1HPGD | |
| SCHEMBL7431663 | 0.71 | HTR6 (0.50) | DYRK1ADYRK1BPRP4KKDM4EALDH1A1 | |
| SCHEMBL6356698 | 0.71 | PTGER1 (0.58) | DYRK1ADYRK1BKDM4EALDH1A1HPGD | |
| SCHEMBL276955 | 0.71 | ALDH1A1 (0.58) | HDAC1KDM4EALDH1A1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050154048-A1 | Novel acyl hydrazino thiophene derivatives, process for preparing them, their use as medicinal products, pharmaceutical compositions and novel use | AVENTIS PHARMA S.A. (FR) | 2005-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050154048-A1 | Novel acyl hydrazino thiophene derivatives, process for preparing them, their use as medicinal products, pharmaceutical compositions and novel use | CTSZ, CTSE, CTSS | DYRK1A 4745/4885DYRK1B 4688/4885HPGDS 301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.