⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3152133 | 1.00 | — | — | |
| SCHEMBL3152141 | 1.00 | — | — | |
| SCHEMBL16366004 | 0.85 | THRB (0.48) | — | |
| SCHEMBL2065710 | 0.85 | THRB (0.48) | — | |
| SCHEMBL21281751 | 0.85 | THRB (0.48) | — | |
| SCHEMBL3422577 | 0.81 | — | — | |
| SCHEMBL2529813 | 0.79 | THRB (0.41) | — | |
| SCHEMBL30668369 | 0.79 | — | — | |
| SCHEMBL77663 | 0.78 | — | — | |
| SCHEMBL15512266 | 0.77 | CA1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210171996-A1 | PROCESS FOR ENANTIOSELECTIVE ENZYMATIC REDUCTION OF KETO COMPOUNDS | DR. REDDY'S LABORATORIES LIMITED (IN) | 2021-06-10 | — | — | US | claimed |
| EP-4423070-A1 | BENZO[H]QUINAZOLINE-4-AMINE DERIVATIVES FOR THE TREATMENT OF CANCER | Redona Therapeutics, Inc. (US) | 2024-09-04 | — | — | EP | disclosed |
| CN-118541354-A | Benzo [ h ] quinazolin-4-amine derivatives for the treatment of cancer | 雷多纳治疗公司 | 2024-08-23 | — | — | CN | disclosed |
| WO-2023196629-A1 | BENZO[H]QUINAZOLINE-4-AMINE DERIVATIVES FOR THE TREATMENT OF CANCER | Redona Therapeutics, Inc. (US) | 2023-10-12 | — | — | WO | disclosed |
| WO-2023072913-A1 | BENZO[H]QUINAZOLINE-4-AMINE DERIVATIVES FOR THE TREATMENT OF CANCER | TWENTYEIGHT-SEVEN, INC. (US) | 2023-05-04 | — | — | WO | disclosed |
| US-20210171996-A1 | PROCESS FOR ENANTIOSELECTIVE ENZYMATIC REDUCTION OF KETO COMPOUNDS | DR. REDDY'S LABORATORIES LIMITED (IN) | 2021-06-10 | — | — | US | disclosed |
| WO-2016021192-A1 | PROCESS FOR PRODUCTION OF (S)-(TETRAHYDROFURAN-3-YL)HYDRAZINE | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2016-02-11 | — | — | WO | disclosed |
| WO-2008093955-A1 | PROCESS FOR THE EFFICIENT PREPARATION OF 3-HYDROXYTETRAHYDROFURAN | RSTECH CORPORATION (KR) | 2008-08-07 | — | — | WO | disclosed |
| US-7262310-B2 | Process for preparing 3-hydroxythiolane | DAISO CO., LTD. (JP) | 2007-08-28 | — | — | US | disclosed |
| US-20050222433-A1 | Process for preparing 3-hydroxythiolane | OSAKA SODA CO., LTD. (JP) | 2005-10-06 | — | — | US | disclosed |
| US-5286857-A | Intermediate for the preparation of penems | PFIZER INC. (US) | 1994-02-15 | — | — | US | disclosed |
| US-5191075-A | Process for the preparation of penems | PFIZER INC (US) | 1993-03-02 | — | — | US | disclosed |
| US-5144042-A | PROCESS FOR PREPARING OPTICALLY ACTIVE 3-HYDROXYPYRROLIDINE DERIVATIVES | TAKASAGO INTERNATIONAL CORPORATION (JP) | 1992-09-01 | — | — | US | disclosed |
| EP-0452143-A2 | Process for preparing optically active 3-hydroxypyrrolidine derivatives | Takasago International Corporation (JP) | 1991-10-16 | — | — | EP | disclosed |
| US-4992543-A | Penem derivatives | PFIZER INC. (US) | 1991-02-12 | — | — | US | disclosed |
| EP-0382418-A2 | Process for optically active 3-thiolanyl sulfonate esters | PFIZER INC. (US) | 1990-08-16 | — | — | EP | disclosed |
| US-4940823-A | Process for optically active 3-thiolanyl sulfonate esters | PFIZER INC. (US) | 1990-07-10 | — | — | US | disclosed |
| US-4921972-A | Process for optically active 3-thiolanyl sulfonate esters | PFIZER INC. (US) | 1990-05-01 | — | — | US | disclosed |
| EP-0365223-A2 | Process for the preparation of penems | PFIZER INC. (US) | 1990-04-25 | — | — | EP | disclosed |
| US-4864046-A | Process for optically active 3-thiolanyl sulfonate esters | PFIZER INC. (US) | 1989-09-05 | — | — | US | disclosed |