Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16366004 | 1.00 | THRB (0.48) | THRBCA1CA2CA9DPP4 | |
| SCHEMBL21281751 | 1.00 | THRB (0.48) | THRBCA1CA2CA9DPP4 | |
| SCHEMBL4787058 | 0.85 | — | — | |
| SCHEMBL3152133 | 0.85 | — | — | |
| SCHEMBL3152141 | 0.85 | — | — | |
| SCHEMBL1888683 | 0.85 | THRB (0.62) | THRBDPP4ALDH1A1USP2CYP3A4 | |
| SCHEMBL25949401 | 0.85 | THRB (0.62) | THRBDPP4ALDH1A1USP2CYP3A4 | |
| SCHEMBL14388243 | 0.82 | THRB (0.59) | THRBDPP4ALDH1A1USP2CYP3A4 | |
| SCHEMBL8721132 | 0.82 | THRB (0.59) | THRBDPP4ALDH1A1USP2CYP3A4 | |
| SCHEMBL13569224 | 0.82 | THRB (0.59) | THRBDPP4ALDH1A1USP2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019159191-A1 | AN IMPROVED PROCESS FOR PREPARATION OF SUGAMMADEX SODIUM | EXTROVIS AG EXTROVIS PRIVATE LIMITED (IN) | 2019-08-22 | — | — | WO | disclosed |
| WO-2014203045-A1 | A NOVEL, GREEN AND COST EFFECTIVE PROCESS FOR SYNTHESIS OF TERT-BUTYL (3R,5S)-6-OXO-3,5-DIHYDROXY-3,5-O-ISOPROPYLIDENE-HEXANOATE | LUPIN LIMITED (IN) | 2014-12-24 | — | — | WO | disclosed |
| EP-1700854-B1 | Intermediates for the preparation of 2-(6-substituted-1,3-dioxane-4-yl) acetic acid derivatives | ASTRAZENECA UK LTD (GB) | 2012-05-23 | — | — | EP | disclosed |
| US-8148324-B2 | Aldolases, nucleic acids encoding them; improving thermal stability of enzyme; biosynthesis of atorvastatin, rosuvastatin, fluvastatin starting from e.g. acetaldehyde and chloroacetaldehyde, using enzyme 2-deoxyribose-5-phosphate aldolase (DERA) to form pyran intermediate | VERENIUM CORPORATION (US) | 2012-04-03 | — | — | US | disclosed |
| US-20110251406-A1 | PROCESS FOR THE PREPARATION OF 2-(6-SUBSTITUTED-1,-3-DIOXANE-4-YL) ACETIC ACID DERIVATIVES | ASTRAZENECA UK LTD. (GB) | 2011-10-13 | — | — | US | disclosed |
| US-7989643-B2 | Process for the preparation of 2-(6-substituted-1,3-dioxane-4-yl)acetic acid derivatives | ASTRAZENECA UK LTD. (GB) | 2011-08-02 | — | — | US | disclosed |
| US-20100136339-A1 | Process for the Preparation of 2-(6-Substituted-1,3-Dioxane-4-yl)Acetic Acid Derivatives | ASTRAZENECA UK LTD. (GB) | 2010-06-03 | — | — | US | disclosed |
| US-7642363-B2 | Process for the preparation of 2-(6-substituted-1,3-dioxane-4-YL) acetic acid derivatives | ASTRAZENECA UK LTD. (GB) | 2010-01-05 | — | — | US | disclosed |
| US-20080289056-A1 | CHEMOENZYMATIC METHODS FOR THE SYNTHESIS OF STATINS AND STATIN INTERMEDIATES | VERENIUM CORPORATION (US) | 2008-11-20 | — | — | US | disclosed |
| US-7414119-B2 | Aldolases, nucleic acids encoding them and methods for making and using them | VERENIUM CORPORATION (US) | 2008-08-19 | — | — | US | disclosed |
| EP-1625223-A2 | CHEMOENZYMATIC METHODS FOR THE SYNTHESIS OF STATINS AND STATIN INTERMEDIATES | Diversa Corporation (US) | 2006-02-15 | — | — | EP | disclosed |
| US-20050153407-A1 | Chemoenzymatic methods for the synthesis of statins and stain intermediates | VERENIUM CORPORATION | 2005-07-14 | — | — | US | disclosed |
| US-20050148785-A1 | Process for the preparation of 2-(6-substituted-1,-3-dioxane-4-YL) acetic acid derivatives | ASTRAZENECA UK LTD. | 2005-07-07 | — | — | US | disclosed |
| US-6870059-B2 | Process for the preparation of 2-(6-substituted-1,-3-dioxane-4-yl)acetic acid derivatives | ASTRAZENECA UK LTD. (GB) | 2005-03-22 | — | — | US | disclosed |
| WO-2004027075-A2 | CHEMOENZYMATIC METHODS FOR THE SYNTHESIS OF STATINS AND STAIN INTERMEDIATES | DIVERSA CORPORATION (US) | 2004-04-01 | — | — | WO | disclosed |
| US-20030158426-A1 | Process for the preparation of 2-(6-subtituted-1,-3-dioxane-4-yl)acetic acid derivatives | ASTRAZENECA UK LTD. (GB) | 2003-08-21 | — | — | US | disclosed |
| EP-1317440-A1 | PROCESS FOR THE PREPARATION OF 2-(6-SUBSTITUTED-1,3-DIOXANE-4-YL)ACETIC ACID DERIVATIVES | DSM N.V. (NL) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002006266-A1 | PROCESS FOR THE PREPARATION OF 2-(6-SUBSTITUTED-1,3-DIOXANE-4-YL)ACETIC ACID DERIVATIVES | DSM N.V. (NL) | 2002-01-24 | — | — | WO | disclosed |
| US-5795749-A | Use of 2-deoxyribose-5-phosphate aldolase to prepare 2-deoxyfucose, analogues and derivatives | THE SCRIPPS RESEARCH INSTITUTION (US) | 1998-08-18 | — | — | US | disclosed |
| WO-1996031615-A1 | USE OF 2-DEOXYRIBOSE-5-PHOSPHATE ALDOLASE TO PREPARE 2-DEOXYFUCOSE, ANALOGUES AND DERIVATIVES | THE SCRIPPS RESEARCH INSTITUTE (US) | 1996-10-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050148785-A1 | Process for the preparation of 2-(6-substituted-1,-3-dioxane-4-YL) acetic acid derivatives | HMGCR, ACOX3, STARD3 | THRB 1848/4885CA1 161/4885CA2 128/4885 |
| US-20100136339-A1 | Process for the Preparation of 2-(6-Substituted-1,3-Dioxane-4-yl)Acetic Acid Derivatives | HMGCR, STARD3, ACOX3 | THRB 1691/4885CA1 155/4885CA2 105/4885 |
| US-20110251406-A1 | PROCESS FOR THE PREPARATION OF 2-(6-SUBSTITUTED-1,-3-DIOXANE-4-YL) ACETIC ACID DERIVATIVES | HMGCR, ACOX3, STARD3 | THRB 2167/4885CA1 127/4885CA2 115/4885 |
| US-20030158426-A1 | Process for the preparation of 2-(6-subtituted-1,-3-dioxane-4-yl)acetic acid derivatives | HMGCR, SRD5A1, CYP11A1 | THRB 1308/4885CA1 136/4885CA2 116/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.