Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.37 |
| ▸ | FABP3 | P05413 | 1/20 | 0.37 |
| ▸ | FABP4 | P15090 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4788717 | 0.95 | MAPT (0.42) | MAPTDHFRTHRBTP53GRM5 | |
| SCHEMBL4789117 | 0.92 | TP53 (0.40) | MAPTDHFRTHRBTP53P2RX3 | |
| SCHEMBL4788000 | 0.88 | LMNA (0.40) | MAPTDHFRTHRBTP53P2RX3 | |
| SCHEMBL4786905 | 0.87 | DHFR (0.45) | MAPTDHFRTHRBTP53GRM5 | |
| SCHEMBL14021050 | 0.86 | MAPT (0.45) | MAPTDHFRTHRBTP53GRM5 | |
| SCHEMBL4788795 | 0.83 | MAPT (0.42) | MAPTDHFRTP53GRM5GRM1 | |
| SCHEMBL4788897 | 0.79 | DHFR (0.44) | MAPTDHFRTHRBTP53GRM5 | |
| SCHEMBL4786029 | 0.76 | MAPT (0.52) | MAPTDHFRTP53GRM5GRM1 | |
| SCHEMBL2116730 | 0.74 | PPARA (0.48) | MAPTDHFRTHRBTP53GRM5 | |
| SCHEMBL4788865 | 0.73 | MAPT (0.43) | MAPTTHRBTP53GRM5GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008134300-A1 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY | IRM LLC (BM) | 2008-11-06 | — | — | WO | claimed |
| WO-2008134300-A1 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY | IRM LLC (BM) | 2008-11-06 | — | — | WO | disclosed |
| WO-2008134300-A1 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY | IRM LLC (BM) | 2008-11-06 | — | — | WO | disclosed |