Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.55 |
| ▸ | KDR | P35968 | 2/20 | 0.55 |
| ▸ | APP | P05067 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.51 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4737141 | 1.00 | EGFR (0.55) | EGFRHDAC1HDAC8HDAC6HDAC2 | |
| SCHEMBL4737097 | 0.99 | APP (0.55) | EGFRHDAC1HDAC8HDAC6HDAC2 | |
| SCHEMBL4742773 | 0.85 | SLC2A1 (0.57) | HDAC1HDAC8HDAC6HDAC2HDAC3 | |
| SCHEMBL4739328 | 0.85 | SLC2A1 (0.57) | HDAC1HDAC8HDAC6HDAC2HDAC3 | |
| SCHEMBL4737772 | 0.85 | SLC2A1 (0.57) | HDAC1HDAC8HDAC6HDAC2HDAC3 | |
| SCHEMBL3960300 | 0.83 | LMNA (0.53) | EGFRHDAC1HDAC8HDAC6HDAC2 | |
| SCHEMBL3109840 | 0.82 | APP (0.65) | EGFRAPPPOLBNR2F2SLC2A1 | |
| SCHEMBL3118629 | 0.79 | APP (0.68) | EGFRAPPPOLBNR2F2SLC2A1 | |
| SCHEMBL4787633 | 0.79 | HDAC1 (0.73) | EGFRHDAC1HDAC8HDAC6HDAC2 | |
| SCHEMBL4737144 | 0.79 | HDAC1 (0.73) | EGFRHDAC1HDAC8HDAC6HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033747-A9 | MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS | CURIS INC (MA) | 2008-07-24 | — | — | WO | disclosed |