Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 4/20 | 0.60 |
| ▸ | BRAF | P15056 | 7/20 | 0.55 |
| ▸ | KDR | P35968 | 2/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.52 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.52 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.52 |
| ▸ | CSF1R | P07333 | 3/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | BTK | Q06187 | 1/20 | 0.50 |
| ▸ | KIT | P10721 | 1/20 | 0.50 |
| ▸ | BMX | P51813 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.48 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4787643 | 0.89 | BRAF (0.70) | RAF1BRAFKDRPDGFRBPDGFRA | |
| SCHEMBL4789334 | 0.87 | BRAF (0.58) | BRAFKDRMAPK14TNNI3KLCK | |
| SCHEMBL4788811 | 0.87 | RAF1 (0.52) | RAF1BRAFKDRPDGFRBPDGFRA | |
| SCHEMBL4790006 | 0.86 | RAF1 (0.51) | RAF1BRAFKDRPDGFRBPDGFRA | |
| SCHEMBL4788889 | 0.86 | BMX (0.53) | RAF1BRAFKDRPDGFRBPDGFRA | |
| SCHEMBL4789698 | 0.85 | RAF1 (0.51) | RAF1BRAFKDRPDGFRBPDGFRA | |
| SCHEMBL4787557 | 0.85 | RAF1 (0.50) | RAF1BRAFKDRPDGFRBPDGFRA | |
| SCHEMBL4790218 | 0.84 | BMX (0.49) | RAF1BRAFKDRPDGFRBPDGFRA | |
| SCHEMBL4787135 | 0.83 | MAP3K7 (0.61) | RAF1BRAFKDRPDGFRBPDGFRA | |
| SCHEMBL4790188 | 0.83 | BTK (0.49) | RAF1KDRMAPK14PIKFYVECSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | claimed |
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |