Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 11/20 | 0.70 |
| ▸ | RAF1 | P04049 | 4/20 | 0.70 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.70 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.70 |
| ▸ | KDR | P35968 | 1/20 | 0.70 |
| ▸ | CSF1R | P07333 | 5/20 | 0.66 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.63 |
| ▸ | KIT | P10721 | 2/20 | 0.62 |
| ▸ | ABL1 | P00519 | 1/20 | 0.57 |
| ▸ | SRC | P12931 | 1/20 | 0.57 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.57 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.57 |
| ▸ | BMX | P51813 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4787637 | 0.89 | RAF1 (0.60) | BRAFRAF1PDGFRBPDGFRAKDR | |
| SCHEMBL4789335 | 0.89 | KCNK3 (0.59) | BRAFRAF1PDGFRBPDGFRAKDR | |
| SCHEMBL4788816 | 0.87 | BRAF (0.62) | BRAFRAF1PDGFRBPDGFRAKDR | |
| SCHEMBL4790008 | 0.87 | BRAF (0.62) | BRAFRAF1PDGFRBPDGFRAKDR | |
| SCHEMBL4788891 | 0.86 | CSF1R (0.61) | BRAFRAF1PDGFRBPDGFRAKDR | |
| SCHEMBL4754823 | 0.86 | CSF1R (0.65) | BRAFRAF1PDGFRBPDGFRAKDR | |
| SCHEMBL4787563 | 0.85 | BRAF (0.59) | BRAFRAF1PDGFRBPDGFRAKDR | |
| SCHEMBL4790220 | 0.84 | LCK (0.62) | BRAFRAF1PDGFRBPDGFRAKDR | |
| SCHEMBL4787141 | 0.83 | CSF1R (0.67) | BRAFRAF1PDGFRAKDRCSF1R | |
| SCHEMBL4789700 | 0.83 | CSF1R (0.57) | BRAFRAF1PDGFRBPDGFRAKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | claimed |
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |