Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 3/20 | 0.58 |
| ▸ | KDR | P35968 | 2/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.58 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 10/20 | 0.57 |
| ▸ | RET | P07949 | 1/20 | 0.52 |
| ▸ | RXFP2 | Q8WXD0 | 1/20 | 0.51 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | AHR | P35869 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | BTK | Q06187 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4789335 | 0.91 | KCNK3 (0.59) | BRAFKDRMAPK14TNNI3KRXFP1 | |
| SCHEMBL4787637 | 0.87 | RAF1 (0.60) | BRAFKDRMAPK14TNNI3KRXFP1 | |
| SCHEMBL2283600 | 0.82 | KDR (0.68) | BRAFKDRMAPK14TNNI3KRXFP1 | |
| SCHEMBL4787643 | 0.80 | BRAF (0.70) | BRAFKDRMAPK14 | |
| SCHEMBL4548668 | 0.79 | KDR (0.71) | BRAFKDRMAPK14TNNI3KRXFP1 | |
| SCHEMBL857777 | 0.78 | PTK6 (0.61) | BRAFKDRMAPK14TNNI3KRET | |
| SCHEMBL25110157 | 0.78 | MAPT (0.45) | KDRRXFP1RETP2RX1MEN1 | |
| SCHEMBL12613307 | 0.78 | AURKB (0.53) | KDRRETMEN1KMT2AGAA | |
| SCHEMBL5423013 | 0.76 | KDR (0.51) | BRAFKDRMAPK14TNNI3KRXFP1 | |
| SCHEMBL28074109 | 0.75 | P2RX1 (0.56) | KDRRXFP1RETP2RX1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | claimed |
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |