Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 2/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.58 |
| ▸ | ESR1 | P03372 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | BRAF | P15056 | 4/20 | 0.55 |
| ▸ | CSF1R | P07333 | 2/20 | 0.55 |
| ▸ | KDR | P35968 | 2/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.55 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | RAF1 | P04049 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4789334 | 0.91 | BRAF (0.58) | RXFP1BRAFKDRMAPK14TNNI3K | |
| SCHEMBL4787643 | 0.89 | BRAF (0.70) | BRAFCSF1RKDRMAPK14RAF1 | |
| SCHEMBL3977917 | 0.80 | JAK3 (0.64) | KCNK3RXFP1ESR1MAPTLMNA | |
| SCHEMBL2283600 | 0.79 | KDR (0.68) | RXFP1BRAFKDRMAPK14TNNI3K | |
| SCHEMBL4787637 | 0.79 | RAF1 (0.60) | RXFP1MAPTBRAFCSF1RKDR | |
| SCHEMBL13708162 | 0.78 | ESR1 (0.52) | KCNK3RXFP1ESR1MAPTKCNK9 | |
| SCHEMBL23041365 | 0.78 | GOT1 (0.51) | KCNK3ESR1MAPTLMNABRAF | |
| SCHEMBL30692257 | 0.77 | MAP3K7 (0.70) | MAPTBRAFCSF1RKDRMAPK14 | |
| SCHEMBL12518525 | 0.77 | MAP3K7 (0.70) | MAPTBRAFCSF1RKDRMAPK14 | |
| SCHEMBL19233425 | 0.77 | KDR (0.81) | BRAFKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | claimed |
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |